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Invitrogen
Phospho-AP2 gamma (Ser434) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-AP2 gamma (Ser434) Antibody (PA5-105357) in WB
Western blot analysis of Phospho-AP2 gamma (Ser434) in MCF7 (Lane 1: treated with phospho-blocking peptide; Lane 2: treated with non-phospho-blocking peptide). Samples were incubated with Phospho-AP2 gamma (Ser434) polyclonal antibody (Product # PA5-105357).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-105357
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TFAP2C(Accession Q92754), corresponding to amino acid residues around phosphorylated Ser434.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of TFAP2C only when phosphorylated at Ser434.
Target Information
The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activating enhancer-binding protein 2 gamma; AP-2.2; AP2-gamma; stimulated by retinoic acid gene 2; Transcription factor AP-2 gamma; Transcription factor ERF-1
Gene Aliases: AA409384; Ap-2.2; AP2gamma; Stra2; Tcfap2c; TFAP2C
UniProt ID: (Mouse) Q61312
Entrez Gene ID: (Mouse) 21420
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein dimerization activity
general transcription factor
negative regulation of transcription from RNA polymerase II promoter
trophectodermal cell differentiation
hair follicle development
keratinocyte development
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
stem cell population maintenance
forebrain neuron fate commitment
cerebral cortex development
cell differentiation
germ-line stem cell population maintenance
somatic stem cell population maintenance
regulation of gene expression, epigenetic
regulation of cell proliferation
skin development
regulation of epidermis development
positive regulation of transcription from RNA polymerase II promoter
sebaceous gland development
dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
epithelial cell proliferation involved in mammary gland duct elongation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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