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Invitrogen
Phospho-LAT (Ser84) Polyclonal Antibody
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Phospho-LAT (Ser84) Antibody (PA5-105400) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-LAT (Ser84) in mouse brain tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-LAT (Ser84) polyclonal antibody (Product # PA5-105400) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-105400
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human LAT(Accession O43561), corresponding to amino acid residues around phosphorylated Ser84.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of LAT only when phosphorylated at ser84.
靶标信息
LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 36 kDa phospho-tyrosine adapter protein; 36 kDa phosphotyrosine adapter protein; Linker for activation of T-cells family member 1; linker protein; p36-38; pp36
基因别名: LAT
UniProt ID: (Mouse) O54957, (Rat) O70601
Entrez Gene ID: (Mouse) 16797, (Rat) 81511
lymphocyte homeostasis
immune system process
inflammatory response
immune response
cellular defense response
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
integrin-mediated signaling pathway
Ras protein signal transduction
positive regulation of signal transduction
gene expression
calcium-mediated signaling
intracellular signal transduction
mast cell degranulation
homeostasis of number of cells
regulation of T cell activation
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