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Invitrogen
Phospho-JunD (Ser259) Polyclonal Antibody
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FIGURE: 1 / 7
Phospho-JunD (Ser259) Antibody (PA5-105513) in ICC/IF
Immunocytochemistry analysis of Phospho-JunD (Ser259) in Hela cells (4h of LPS treatment). The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Phospho-JunD (Ser259) polyclonal antibody (Product # PA5-105513) 1:200 and mouse anti-beta tubulin antibody (1:200) for 1 hour at 37°C. An AlexaFluor594 conjugated goat ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-105513
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human JUND(Accession P17535), corresponding to amino acid residues around phosphorylated Ser259.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of JunD only when phosphorylated at Ser259.
Target Information
JunD is a transcription factor which is coded by JunD gene. JunD transcriptional activity is modulated by phosphorylation in response to cellular stress via the c-Jun N terminal kinase (JNK)/Stress-Activated Protein Kinase (SAPK) family of protein kinase. Jun proteins are capable of forming dimers with Fos, ATF and CREB family transcription factors to form the AP-1 complex that differentially regulates a variety of target genes involved in cellular growth, proliferation, differentiation and apoptosis. Also, JunD plays an important role in metabolism via modulation of IGF-1 signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AP1; JUN D; Jun proto-oncogene related gene d; Jun proto-oncogene related gene d1; JunD-FL isoform; Oncogene Jun-D; Transcription factor AP-1 subunit JunD; transcription factor jun-D; Transcription factor JunD
Gene Aliases: Jun-d; JUND; Jund1
UniProt ID: (Rat) P52909, (Mouse) P15066
Entrez Gene ID: (Rat) 24518, (Mouse) 16478
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
ligand-dependent nuclear receptor binding
enzyme binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
transcription factor binding
basic leucine zipper transcription factor
osteoblast development
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
aging
circadian rhythm
response to light stimulus
response to mechanical stimulus
response to organic cyclic compound
response to lipopolysaccharide
response to peptide hormone
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
cellular response to calcium ion
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
response to radiation
regulation of cell death
cellular response to hormone stimulus
response to cytokine
regulation of cell proliferation
response to drug
response to cAMP
regulation of cell cycle
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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