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Invitrogen
Phospho-FGFR4 (Tyr642) Polyclonal Antibody
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Phospho-FGFR4 (Tyr642) Antibody (PA5-105531) in ICC/IF
Immunocytochemistry analysis of Phospho-FGFR4 (Tyr642) in Hela cells (heat shock treatment). The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Phospho-FGFR4 (Tyr642) polyclonal antibody (Product # PA5-105531) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-105531
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human FGFR4(Accession P22455), corresponding to amino acid residues around phosphorylated Tyr642.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of FGFR4 only when phosphorylated at Tyr642.
靶标信息
FGFR4 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR4 is required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. FGFR4 plays a role in postnatal lung development and may be involved in the development of skeletal muscle cell lineages.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD334; CTLA-2-beta protein; FGF Receptor; FGF Receptor 4; FGFR; FGFR-4; Fibroblast growth factor receptor 4; fibroblast growth factor receptor 4 16 minus form; MGC20292; Protein-tyrosine kinase receptor MPK-11
基因别名: Fgfr-4; FGFR4; JTK2; Mpk-11; TKF
UniProt ID: (Rat) Q498D6, (Mouse) Q03142
Entrez Gene ID: (Rat) 25114, (Mouse) 14186
fibroblast growth factor-activated receptor activity
ATP binding
heparin binding
fibroblast growth factor binding
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
organ induction
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
positive regulation of gene expression
regulation of extracellular matrix disassembly
cell migration
peptidyl-tyrosine phosphorylation
regulation of lipid metabolic process
lung development
glucose homeostasis
positive regulation of catalytic activity
positive regulation of proteolysis
protein autophosphorylation
phosphate ion homeostasis
alveolar secondary septum development
positive regulation of ERK1 and ERK2 cascade
regulation of bile acid biosynthetic process
response to bile acid
regulation of cholesterol homeostasis
positive regulation of DNA biosynthetic process
protein phosphorylation
phosphorylation
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