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Invitrogen
Phospho-RSK2 (Thr577) Polyclonal Antibody
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图: 1 / 4
Phospho-RSK2 (Thr577) Antibody (PA5-105587) in ICC/IF
Immunocytochemistry analysis of Phospho-RSK2 (Thr577) in HepG2 cells (4h of LPS treatment). The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Phospho-RSK2 (Thr577) polyclonal antibody (Product # PA5-105587) 1:200 and mouse anti-beta tubulin antibody (1:200) for 1 hour at 37°C. An AlexaFluor594 conjugated goat... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-105587
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human RPS6KA3(Accession P51812), corresponding to amino acid residues around phosphorylated Thr577.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of RSK2 only when phosphorylated at Thr577.
靶标信息
RPS6KA3 (RSK2) is a serine/threonine kinase that modulates many cellular processes including transcription, adhesion, growth, survival, and proliferation. RPS6KA3 contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in the gene have been associated with Coffin-Lowry syndrome (CLS).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 90 kDa ribosomal protein S6 kinase 3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; p90-RSK 3; pp90RSK2; ribosomal protein S6 kinase 2; Ribosomal protein S6 kinase alpha-3; Ribosomal S6 kinase 2; RSK-2; S6K-alpha-3
基因别名: C130006E23; ISPK1; MAPKAPK-1b; MAPKAPK1B; MPK-9; p90RSK3; pp90RSK2; RGD1563860; Rps6ka-rs1; RPS6KA3; RSK2; S6K-alpha3
UniProt ID: (Mouse) P18654
Entrez Gene ID: (Mouse) 110651, (Rat) 501560
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
ribosomal protein S6 kinase activity
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein kinase binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
molecular_function
protein modifying enzyme
toll-like receptor signaling pathway
regulation of translation
protein phosphorylation
cell cycle
phosphorylation
response to lipopolysaccharide
intracellular signal transduction
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of transcription from RNA polymerase II promoter
biological_process
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