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Invitrogen
Phospho-Cdc20 (Thr70) Polyclonal Antibody
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Phospho-Cdc20 (Thr70) Antibody (PA5-105704) in WB
Western blot analysis of Phospho-Cdc20 (Thr70) in extracts from various samples. Samples were incubated with Phospho-Cdc20 (Thr70) polyclonal antibody (Product # PA5-105704). Lane 1: K562 cells (heat-shock treatment), blocked with antigen-specific peptides; Lane 2: K562 cells (heat-shock treatment); Lane 3: Mcf7 cells (heat-shock treatment).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-105704
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CDC20(Accession Q12834), corresponding to amino acid residues around phosphorylated Thr70.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of CDC20 only when phosphorylated at Thr70.
靶标信息
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cell cycle protein p55CDC; cell division cycle 20 homolog; Cell division cycle protein 20 homolog; mmCdc20; p55CDC
基因别名: 2310042N09Rik; C87100; CDC20; p55CDC
UniProt ID: (Rat) Q62623, (Mouse) Q9JJ66
Entrez Gene ID: (Rat) 64515, (Mouse) 107995
mitotic nuclear division
positive regulation of cell proliferation
protein ubiquitination
anaphase-promoting complex-dependent catabolic process
positive regulation of synaptic plasticity
regulation of meiotic nuclear division
regulation of dendrite development
cell division
positive regulation of synapse maturation
positive regulation of ubiquitin protein ligase activity
cell cycle
nervous system development
cell differentiation
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