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Invitrogen
BRCA2 Polyclonal Antibody
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FIGURE: 1 / 3
BRCA2 Antibody (PA5-105731) in ICC/IF
Immunofluorescent analysis of BRCA2 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and BRCA2 polyclonal antibody (Product # PA5-105731) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-105731
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human BRCA2(Accession P51587), corresponding to amino acid residues E2070-S2120.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total BRCA2.
Target Information
Breast Cancer Type 2 susceptibility protein (BRCA2) is a tumor-suppressor protein reported to be involved in double-strand break repair, homologous recombination and S-phase checkpoint activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brca 2; brca-2; breast cancer 2, mutation 1, University of Wisconsin-Madison; breast cancer susceptibility protein 2; Breast cancer type 2 susceptibility protein; Breast cancer type 2 susceptibility protein homolog; FANCB; Fanconi anemia group D1 protein; Fanconi anemia group D1 protein homolog; RP11-298P3.4
Gene Aliases: BRCA2; FACD; FANCD1; RAB163
UniProt ID: (Mouse) P97929
Entrez Gene ID: (Mouse) 12190, (Rat) 360254
double-strand break repair via homologous recombination
cytokinesis
oocyte maturation
inner cell mass cell proliferation
DNA repair
nucleotide-excision repair
double-strand break repair
DNA recombination
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
cell cycle
male meiosis I
spermatogenesis
brain development
cell aging
cell proliferation
female gonad development
intrinsic apoptotic signaling pathway in response to DNA damage
response to X-ray
response to UV-C
response to gamma radiation
hemopoiesis
mammary gland development
chromosome breakage
homologous chromosome orientation involved in meiotic metaphase I plate congression
regulation of cytokinesis
negative regulation of mammary gland epithelial cell proliferation
multicellular organism growth
regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
chordate embryonic development
histone H3 acetylation
histone H4 acetylation
positive regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle
replication fork protection
chromosome organization
centrosome duplication
response to nutrient
response to estradiol
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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