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Invitrogen
Afadin Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-105733
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human AFDN(Accession P55196), corresponding to amino acid residues L1205-K1255.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Afadin.
Target Information
AFDN belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ALL-1 fusion partner from chromosome 6; ALL1-fused gene from chromosome 6 protein; F-actin binding protein; FLJ34371; fusion gene; large splicing variant of AF-6 protein; myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4; myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4; protein AF-6; RP3-431P23.3; RP3-470B24.4; small splicing variant of l-Afadin; translocated to, 4; unnamed protein product
Gene Aliases: 5033403D15Rik; Af-6; AF6; Afadin; Gm314; I-afadin; l-afadin; MLL-AF6; MLLT4; S-afadin
UniProt ID: (Human) P55196, (Mouse) Q9QZQ1, (Rat) O35889
Entrez Gene ID: (Human) 4301, (Mouse) 17356, (Rat) 26955
signal transduction
positive regulation of gene expression
telencephalon development
cerebral cortex development
positive regulation of cell-cell adhesion
cell differentiation
negative regulation of cell migration
cell junction organization
adherens junction maintenance
cell-cell adhesion mediated by cadherin
pore complex assembly
brain morphogenesis
homeostasis of number of cells
positive regulation of dendrite morphogenesis
radial glial cell differentiation
neuroepithelial cell differentiation
positive regulation of dendritic spine morphogenesis
positive regulation of mini excitatory postsynaptic potential
establishment of protein localization to plasma membrane
regulation of oligodendrocyte progenitor proliferation
bicellular tight junction assembly
establishment of endothelial intestinal barrier
postsynaptic specialization organization
regulation of postsynapse organization
dendrite arborization
regulation of postsynapse assembly
protein localization to cell junction
positive regulation of dendrite extension
positive regulation of cell-cell adhesion mediated by cadherin
cell adhesion
cell-cell signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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