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Invitrogen
Phospho-KV4.2 (KCND2) (Ser616) Polyclonal Antibody
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FIGURE: 1 / 3
Phospho-KV4.2 (KCND2) (Ser616) Antibody (PA5-105812) in IHC (P)
Immunohistochemistry analysis of Phospho-KV4.2 (KCND2) (Ser616) in mouse brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Phospho-KV4.2 (KCND2) (Ser616) polyclonal antibody (Product # PA5-105812) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-105812
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human KCND2(Accession Q9NZV8), corresponding to amino acid residues around phosphorylated Ser616.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of Kv4.2/KCND2 only when phosphorylated at Ser616.
Target Information
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes-shaker, shaw, shab, and shal-have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A-type voltage-gated potassium channel KCND2; potassium channel Kv4.2; potassium channel, voltage gated Shal related subfamily D, member 2; potassium voltage gated channel, Shal-related family, member 2; Potassium voltage-gated channel subfamily D member 2; potassium voltage-gated channel, Shal-related subfamily, member 2; RK5; Shal1; Voltage-gated potassium channel subunit Kv4.2; voltage-sensitive potassium channel
Gene Aliases: AI839615; AW555701; KCND2; KIAA1044; KV4.2; mKIAA1044; MNCb-7013; R75121; RK5; Shal1
UniProt ID: (Human) Q9NZV8, (Rat) Q63881, (Mouse) Q9Z0V2
Entrez Gene ID: (Human) 3751, (Rat) 65180, (Mouse) 16508
ion channel activity
voltage-gated potassium channel activity
A-type (transient outward) potassium channel activity
potassium channel activity
protein binding
metal ion binding
voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
delayed rectifier potassium channel activity
protein heterodimerization activity
voltage-gated ion channel activity
voltage-gated ion channel
action potential
ion transport
potassium ion transport
muscle contraction
chemical synaptic transmission
regulation of heart contraction
neuronal action potential
sensory perception of pain
ion transmembrane transport
locomotor rhythm
protein homooligomerization
transmembrane transport
regulation of postsynaptic membrane potential
cellular response to hypoxia
potassium ion transmembrane transport
membrane repolarization
regulation of ion transmembrane transport
cellular response to drug
protein heterooligomerization
cellular response to mechanical stimulus
cardiac muscle cell action potential
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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