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Invitrogen

Phospho-EphB1/EphB2/EphB3/EphB4 (Tyr600, Tyr602, Tyr614, Tyr596) Polyclonal Antibody

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Phospho-EphB1/EphB2/EphB3/EphB4 (Tyr600, Tyr602, Tyr614, Tyr596) Polyclonal Antibody

Product Details

PA5-105878

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human EPHB1(Accession P54762), corresponding to amino acid residues around phosphorylated Tyr596.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817277

Product Specific Information

Antibody detects endogenous levels of EPHB1/2/3/4 only when phosphorylated at Tyr600/602/614/596.

Target Information

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Developmental kinase 2; Developmental kinase 5; Developmentally-regulated Eph-related tyrosine kinase; EK2; EK5; EK6; ELK; ELK-related protein tyrosine kinase; ELK-related tyrosine kinase; Embryonic kinase 2; Eph receptor B2 (ELK-related protein tyrosine kinase); EPH receptor B4; EPH tyrosine kinase 2; EPH tyrosine kinase 3; EPH-like kinase 2; EPH-like kinase 5; EPH-like kinase 6; EPH-like tyrosine kinase 2; EPH-like tyrosine kinase-2; Ephrin type-B receptor 1; Ephrin type-B receptor 2; Ephrin type-B receptor 3; Ephrin type-B receptor 4; Hepatoma transmembrane kinase; mDK-2; mDK-5; NET; Neural kinase; Neuronally-expressed EPH-related tyrosine kinase; Nuk receptor tyrosine kinase; Renal carcinoma antigen NY-REN-47; Tyrosine kinase MYK-1; Tyrosine-protein kinase receptor EPH-2; Tyrosine-protein kinase receptor EPH-3; Tyrosine-protein kinase receptor SEK-3; Tyrosine-protein kinase receptor SEK-4; Tyrosine-protein kinase TYRO11; Tyrosine-protein kinase TYRO5; Tyrosine-protein kinase TYRO6

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Gene Aliases: 9330129L11; AI042935; AW456895; AW488255; C130099E04Rik; Cek10; Cek5; Cek6; DRT; ELK; Elkh; ENSMUSG00000074119; EPHB1; EPHB2; EPHB3; EPHB4; EPHT2; EPHT3; Epth2; EPTH3; ERK; ETECK; ETK2; HEK2; HEK5; HEK6; HTK; MDK2; MDK5; MYK1; NET; Nuk; Prkm5; Qek5; RGD1564232; Sek3; Sek4; TYRO11; TYRO5; TYRO6

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UniProt ID: (Rat) P09759, (Mouse) Q8CBF3, (Mouse) P54763, (Mouse) P54754, (Mouse) P54761

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Entrez Gene ID: (Rat) 24338, (Mouse) 270190, (Mouse) 13844, (Rat) 313633, (Mouse) 13845, (Rat) 287989, (Rat) 686310, (Mouse) 13846

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Function(s)
protein tyrosine kinase activity ephrin receptor activity transmembrane-ephrin receptor activity ATP binding axon guidance receptor activity protein complex binding nucleotide binding protein kinase activity transmembrane receptor protein tyrosine kinase activity protein binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups receptor activity receptor binding identical protein binding molecular_function transmembrane signal receptor
Process(es)
angiogenesis immunological synapse formation axon guidance peptidyl-tyrosine phosphorylation cranial nerve development optic nerve morphogenesis central nervous system projection neuron axonogenesis neurogenesis establishment of cell polarity retinal ganglion cell axon guidance cell-substrate adhesion regulation of JNK cascade protein autophosphorylation ephrin receptor signaling pathway camera-type eye morphogenesis detection of temperature stimulus involved in sensory perception of pain positive regulation of synapse assembly cell chemotaxis dendritic spine development dendritic spine morphogenesis neural precursor cell proliferation regulation of ERK1 and ERK2 cascade regulation of neuron death protein phosphorylation cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway nervous system development phosphorylation cell morphogenesis urogenital system development multicellular organism development axonal fasciculation learning organ morphogenesis corpus callosum development inner ear morphogenesis regulation of neuronal synaptic plasticity positive regulation of long-term neuronal synaptic plasticity regulation of axonogenesis negative regulation of axonogenesis regulation of body fluid levels palate development commissural neuron axon guidance biological_process signal transduction cell migration regulation of cell-cell adhesion substrate adhesion-dependent cell spreading regulation of GTPase activity thymus development digestive tract morphogenesis cell migration involved in sprouting angiogenesis heart morphogenesis
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