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Invitrogen
Phospho-HIPK1/HIPK2/HIPK3 (Tyr352, Tyr361, Tyr359) Polyclonal Antibody
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Phospho-HIPK1/HIPK2/HIPK3 (Tyr352, Tyr361, Tyr359) Antibody (PA5-105887) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-HIPK1/HIPK2/HIPK3 (Tyr352, Tyr361, Tyr359) in mouse gastric tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-HIPK1/HIPK2/HIPK3 (Tyr352, Tyr361, Tyr359) polyclonal antibody (Product # PA5-105887) using a dilution of 1:200 (1.5 hr, 22°C), followed by... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-105887
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human HIPK1(Accession Q86Z02), corresponding to amino acid residues around phosphorylated Tyr352.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of HIPK1/2/3 only when phosphorylated at Tyr352/361/359.
靶标信息
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Androgen receptor-interacting nuclear protein kinase; ANPK; Fas-interacting serine/threonine-protein kinase; FIST; HCMV-interacting protein; hHIPk2; hipk1 {ECO:0000312|EMBL:ABO47653.1}; Homeodomain-interacting protein kinase 1; Homeodomain-interacting protein kinase 2; Homeodomain-interacting protein kinase 3; Homolog of protein kinase YAK1; Nbak3; Nuclear body-associated kinase 1; Nuclear body-associated kinase 2; Nuclear body-associated kinase 3; nuclear serine/threonine protein kinase; Protein kinase Myak; Sialophorin tail-associated nuclear serine/threonine-protein kinase
基因别名: 1110014O20Rik; 1110062K04Rik; ANPK; B230339E18Rik; DYRK6; Fist; FIST3; HIPK1; HIPK2; HIPK3; KIAA0630; mir-1902; MYAK; Nbak1; NBAK2; PKY; Stank
UniProt ID: (Mouse) O88904, (Mouse) Q9QZR5, (Mouse) Q9ERH7, (Rat) O88850
Entrez Gene ID: (Rat) 365895, (Mouse) 15257, (Rat) 362342, (Mouse) 15258, (Mouse) 15259, (Rat) 83617
protein serine/threonine kinase activity
ATP binding
nucleotide binding
DNA binding
transcription corepressor activity
protein kinase activity
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
RNA polymerase II activating transcription factor binding
RNA polymerase II transcription coactivator activity
SMAD binding
virion binding
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
apoptotic process
mRNA transcription
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
negative regulation of apoptotic process
positive regulation of DNA binding
negative regulation of JUN kinase activity
smoothened signaling pathway
positive regulation of cell proliferation
anterior/posterior pattern specification
regulation of tumor necrosis factor-mediated signaling pathway
retina layer formation
neuron differentiation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
embryonic camera-type eye morphogenesis
embryonic retina morphogenesis in camera-type eye
lens induction in camera-type eye
iris morphogenesis
endothelial cell apoptotic process
extrinsic apoptotic signaling pathway
positive regulation of protein phosphorylation
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
transforming growth factor beta receptor signaling pathway
adult walking behavior
adult locomotory behavior
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
positive regulation of protein binding
negative regulation of neuron apoptotic process
positive regulation of angiogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
voluntary musculoskeletal movement
positive regulation of sequence-specific DNA binding transcription factor activity
SMAD protein signal transduction
cellular response to DNA damage stimulus
negative regulation of nucleic acid-templated transcription
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