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Invitrogen

Phospho-HIPK1/HIPK2/HIPK3 (Tyr352, Tyr361, Tyr359) Polyclonal Antibody

View all (2) HIPK1/HIPK2/HIPK3 antibodies

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Phospho-HIPK1/HIPK2/HIPK3 (Tyr352, Tyr361, Tyr359) Polyclonal Antibody

Product Details

PA5-105887

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human HIPK1(Accession Q86Z02), corresponding to amino acid residues around phosphorylated Tyr352.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817286

Product Specific Information

Antibody detects endogenous levels of HIPK1/2/3 only when phosphorylated at Tyr352/361/359.

Target Information

The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: androgen receptor-interacting nuclear protein kinase; ANPK; CD43 associated protein kinase; fas-interacting serine/threonine-protein kinase; FIST; FIST3; protein kinase; HCMV-interacting protein; hHIPk2; HIPK1; HIPK2; HIPK2a; HIPK2b; HIPK3; homeodomain interacting protein kinase 1-like protein; homolog of protein kinase YAK1; nbak3; nuclear body associated kinase 2b; nuclear body-associated kinase 1; nuclear body-associated kinase 2; nuclear body-associated kinase 3; nuclear serine/threonine protein kinase; predicted protein of HQ0593; protein kinase Myak; protein kinase NBAK1a; protein kinase NBAK1b; protein kinase NBAK2a; protein kinase NBAK2b; protein kinase NBAK3; sialophorin tail-associated nuclear serine/threonine-protein kinase; unnamed protein product

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Gene Aliases: 1110014O20Rik; 1110062K04Rik; ANPK; B230339E18Rik; DYRK6; FIST3; mir-1902; Myak; Nbak2; PKY; PRO0593; Stank; YAK1

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UniProt ID: (Human) Q86Z02, (Human) Q9H2X6, (Human) Q9H422, (Mouse) O88904, (Mouse) Q9QZR5, (Rat) O88850, (Mouse) Q9ERH7

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Entrez Gene ID: (Human) 204851, (Human) 28996, (Human) 10114, (Mouse) 15257, (Rat) 365895, (Rat) 362342, (Mouse) 15258, (Rat) 83617, (Mouse) 15259

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Function(s)
protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity protein binding ATP binding protein serine kinase activity transcription coactivator activity transcription corepressor activity SMAD binding virion binding RNA polymerase II sequence-specific DNA binding transcription factor binding DNA binding nucleotide binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter eye development protein phosphorylation smoothened signaling pathway retina layer formation peptidyl-serine phosphorylation neuron differentiation erythrocyte differentiation DNA damage response, signal transduction by p53 class mediator positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway PML body organization regulation of gene expression, epigenetic intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade embryonic camera-type eye morphogenesis regulation of cell cycle embryonic retina morphogenesis in camera-type eye lens induction in camera-type eye SMAD protein signal transduction iris morphogenesis cellular response to hypoxia intrinsic apoptotic signaling pathway regulation of signal transduction by p53 class mediator negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of cell proliferation anterior/posterior pattern specification regulation of tumor necrosis factor-mediated signaling pathway adherens junction assembly positive regulation of DNA binding endothelial cell apoptotic process extrinsic apoptotic signaling pathway positive regulation of protein phosphorylation respiratory system process transforming growth factor beta receptor signaling pathway adult walking behavior adult locomotory behavior gene expression thyroid gland development negative regulation of neuron apoptotic process voluntary musculoskeletal movement lung morphogenesis mRNA transcription peptidyl-threonine phosphorylation negative regulation of apoptotic process negative regulation of JUN kinase activity definitive hemopoiesis
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