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Invitrogen
Phospho-cGKII (Ser126) Polyclonal Antibody
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Phospho-cGKII (Ser126) Antibody (PA5-105913) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-cGKII (Ser126) in human pancreas tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-cGKII (Ser126) polyclonal antibody (Product # PA5-105913) using a dilution of 1:200 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-105913
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PRKG2(Accession Q13237), corresponding to amino acid residues around phosphorylated Ser126.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of CGK2 only when phosphorylated at Ser126.
靶标信息
PRKG2 (PKG2, cGKII) exhibits many cellular functions and has cAMP- and cGMP-dependent protein kinase activity. cGKII is thought to play a key role in a diverse set of physiological pathway. cGKII may mediate intestinal secretion of water and electrolytes induced by the E. coli toxin STa and the intestinal peptide guanylin. Identification of the pathway that mediates intestinal fluid secretion by E. coli. cGKII is postulated to be a molecular switch that couples the cessation of proliferation and the start of hypertrophic chondrocyte differentiation through attenuating SOX9 function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CGK 2; cGK2; cGKII; cGMP dependent protein kinase type II; cGMP-dependent protein kinase 2; cGMP-dependent protein kinase II; EC 2.7.11.12; protein kinase cGMP- dependent type 2; protein kinase, cGMP- dependent, type 2; protein kinase, cGMP- dependent, type II; type II cGMP-dependent protein kinase
基因别名: AW212535; cGK-II; CGKII; GDPKII; PRKG2; PRKGR2
UniProt ID: (Rat) Q64595
Entrez Gene ID: (Rat) 25523, (Mouse) 19092
cGMP-dependent protein kinase activity
ATP binding
cGMP binding
protein homodimerization activity
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
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