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Invitrogen

Phospho-TGFBR2 (Tyr284) Polyclonal Antibody

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Phospho-TGFBR2 (Tyr284) Polyclonal Antibody

Product Details

PA5-105920

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TGFBR2(Accession P37173), corresponding to amino acid residues around phosphorylated Tyr284.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817319

Product Specific Information

Antibody detects endogenous levels of TGFBR2 only when phosphorylated at Tyr284.

Target Information

Transforming Growth Factor, beta receptor 2 (AAT3, FAA3, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII) is a member of the TGF-beta family of receptor Serine/Threonine kinases. It is involved in the regulation of cell proliferation. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). TGFBR2 encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. TGFBR2 also has a pseudogene on chromosome 14.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: tbetaR-II; tgf beta receptor 2; TGF-beta receptor II; TGF-beta receptor type II; TGF-beta receptor type-2; TGF-beta type II receptor; TGFbeta RII; TGFR-2; TGFR2; transforming growth factor beta receptor type II; transforming growth factor, beta receptor II; transforming growth factor, beta receptor IIT; transforming growth factor-b type II receptor; Transforming growth factor-beta receptor type II; transforming growth factor-beta type II receptor

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Gene Aliases: 1110020H15Rik; AU042018; DNIIR; RIIDN; TbetaR-II; TbetaRII; TBR-II; TGF-beta 2; TGFBR2; Tgfbr2T

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UniProt ID: (Rat) P38438, (Mouse) Q62312

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Entrez Gene ID: (Rat) 81810, (Mouse) 21813

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Function(s)
transmembrane receptor protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type II protein binding ATP binding glycosaminoglycan binding mitogen-activated protein kinase kinase kinase binding type I transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding protein homodimerization activity SMAD binding metal ion binding protein heterodimerization activity transforming growth factor beta binding nucleotide binding protein kinase activity protein serine/threonine kinase activity receptor activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
Process(es)
patterning of blood vessels vasculogenesis response to hypoxia in utero embryonic development positive regulation of mesenchymal cell proliferation lens development in camera-type eye positive regulation of tolerance induction to self antigen positive regulation of B cell tolerance induction positive regulation of T cell tolerance induction growth plate cartilage development growth plate cartilage chondrocyte growth protein phosphorylation receptor-mediated endocytosis apoptotic process transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway common-partner SMAD protein phosphorylation smoothened signaling pathway gastrulation brain development heart development embryo implantation aging response to nutrient negative regulation of cell proliferation response to mechanical stimulus response to glucose organ morphogenesis response to organic substance regulation of gene expression positive regulation of epithelial cell migration response to organic cyclic compound peptidyl-serine phosphorylation peptidyl-threonine phosphorylation signal transduction by protein phosphorylation lung development organ regeneration activation of protein kinase activity embryonic hemopoiesis wound healing regulation of cell proliferation response to drug myeloid dendritic cell differentiation positive regulation of skeletal muscle tissue regeneration response to estrogen positive regulation of angiogenesis response to steroid hormone digestive tract development positive regulation of smooth muscle cell proliferation embryonic cranial skeleton morphogenesis positive regulation of NK T cell differentiation cartilage development palate development negative regulation of cardiac muscle cell proliferation pathway-restricted SMAD protein phosphorylation lung morphogenesis bronchus development bronchus morphogenesis trachea morphogenesis trachea formation mammary gland morphogenesis lung lobe morphogenesis response to cholesterol lens fiber cell apoptotic process positive regulation of reactive oxygen species metabolic process Notch signaling pathway phosphorylation cell differentiation regulation of growth
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