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Invitrogen

Phospho-LRP6 (Ser1490) Polyclonal Antibody

View all (26) LRP6 antibodies

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Phospho-LRP6 (Ser1490) Polyclonal Antibody

Product Details

PA5-106064

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human LRP6(Accession O75581), corresponding to amino acid residues around phosphorylated Ser1490.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817463

Product Specific Information

Antibody detects endogenous levels of LRP6 only when phosphorylated at Ser1490.

Target Information

LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: crooked; FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; low density lipoprotein-related protein 6; Low-density lipoprotein receptor-related protein 6; lpr6; LRP-6

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Gene Aliases: C030016K15Rik; Cd; Gw; LRP6; ska26; ska; skax26

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UniProt ID: (Mouse) O88572

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Entrez Gene ID: (Mouse) 16974

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Function(s)
low-density lipoprotein receptor activity receptor binding frizzled binding protein binding Wnt-protein binding kinase inhibitor activity toxin transporter activity apolipoprotein binding identical protein binding protein homodimerization activity Wnt-activated receptor activity coreceptor activity involved in Wnt signaling pathway apolipoprotein
Process(es)
gastrulation with mouth forming second somitogenesis neural tube closure negative regulation of protein phosphorylation heart looping morphogenesis of an epithelium positive regulation of mesenchymal cell proliferation pericardium morphogenesis axis elongation regulation of transcription, DNA-templated negative regulation of protein kinase activity endocytosis receptor-mediated endocytosis positive regulation of cytosolic calcium ion concentration chemical synaptic transmission multicellular organism development embryonic pattern specification dorsal/ventral axis specification anterior/posterior pattern specification neural crest formation neural crest cell differentiation Wnt signaling pathway single organismal cell-cell adhesion cerebellum morphogenesis thalamus development cerebral cortex cell migration forebrain radial glial cell differentiation forebrain generation of neurons Wnt signaling pathway involved in forebrain neuroblast division neural tube development formation of radial glial scaffolds cerebral cortex development negative regulation of Wnt signaling pathway embryonic limb morphogenesis forebrain development midbrain development midbrain-hindbrain boundary development negative regulation of smooth muscle cell apoptotic process limb morphogenesis embryonic forelimb morphogenesis embryonic hindlimb morphogenesis external genitalia morphogenesis post-anal tail morphogenesis cell migration involved in gastrulation regulation of cell proliferation odontogenesis of dentin-containing tooth embryonic digit morphogenesis positive regulation of apoptotic process Wnt signaling pathway involved in dorsal/ventral axis specification negative regulation of fat cell differentiation positive regulation of ossification positive regulation of bone resorption positive regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter bone remodeling embryonic camera-type eye morphogenesis generation of neurons skeletal system morphogenesis negative regulation of epithelial cell proliferation positive regulation of sequence-specific DNA binding transcription factor activity response to folic acid palate development convergent extension retina morphogenesis in camera-type eye embryonic retina morphogenesis in camera-type eye canonical Wnt signaling pathway regulation of cell development face morphogenesis bone morphogenesis branching involved in mammary gland duct morphogenesis trachea cartilage morphogenesis mammary placode formation mammary gland duct morphogenesis canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation cellular response to cholesterol dopaminergic neuron differentiation negative regulation of protein serine/threonine kinase activity primitive streak formation receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport Wnt signaling pathway involved in somitogenesis axis elongation involved in somitogenesis positive regulation of canonical Wnt signaling pathway toxin transport negative regulation of non-canonical Wnt signaling pathway positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis negative regulation of planar cell polarity pathway involved in pericardium morphogenesis negative regulation of planar cell polarity pathway involved in neural tube closure
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