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Invitrogen

Phospho-PLCG1 (Ser1248) Polyclonal Antibody

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Phospho-PLCG1 (Ser1248) Polyclonal Antibody

Product Details

PA5-106101

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PLCG1(Accession P19174), corresponding to amino acid residues around phosphorylated Ser1248.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817500

Product Specific Information

Antibody detects endogenous levels of PLCG1 only when phosphorylated at Ser1248.

Target Information

The mammalian Phospholipase Cg (PLCg) family has two closely related proteins, PLCg1 and PLCg2. The PLCg isozymes have the core structure domains and a unique array of domains containing an additional PH domain, two SH2 domains and one SH3 domain. In response to extracellular stimuli, such as hormones and growth factors, receptor tyrosine kinases (RTKs) phosphorylate and activate PLCg. Activated PLCg catalyzes hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to produce the metabolic second messenger molecules inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; cell differentiation and embryonic development; EC 3.1.4.11; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; OTTHUMP00000178982; phosphatidylinositol phospholipase C; phosphoinositidase C; phosphoinositide phospholipase C; phosphoinositide phospholipase C-gamma-1; phospholipase C; phospholipase C, gamma 1 (formerly subtype 148); phospholipase C-1; phospholipase C-148; phospholipase C-gamma; phospholipase C-II; Phospholipase C2; PLC gamma1; PLC-148; PLC-gamma-1; PLC-II; PLC2I; similar to PLC gamma 1; triphosphoinositide phosphodiesterase; unnamed protein product

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Gene Aliases: Cded; IDAA; NCKAP3; Plc-1; Plc-gamma1; PLC-II; PLC1; PLC148; Plcg-1; PLCgamma1; PPLCA

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UniProt ID: (Human) P19174, (Rat) P10686, (Mouse) Q62077

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Entrez Gene ID: (Human) 5335, (Rat) 25738, (Mouse) 18803

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Function(s)
phosphatidylinositol phospholipase C activity phospholipase C activity guanyl-nucleotide exchange factor activity neurotrophin TRKA receptor binding calcium ion binding protein binding phosphoric diester hydrolase activity protein kinase binding phosphatidylinositol phospholipase C activity lysophospholipase C activity insulin receptor binding receptor tyrosine kinase binding glutamate receptor binding phosphoprotein binding
Process(es)
in utero embryonic development lipid metabolic process calcium ion transport signal transduction epidermal growth factor receptor signaling pathway phospholipid catabolic process response to gravity positive regulation of epithelial cell migration cell migration calcium-mediated signaling positive regulation of cell migration phosphatidylinositol catabolic process inositol trisphosphate metabolic process inositol trisphosphate biosynthetic process intracellular signal transduction response to hydrogen peroxide positive regulation of blood vessel endothelial cell migration positive regulation of angiogenesis positive regulation of cell size phosphatidylinositol metabolic process phosphatidylinositol-mediated signaling modulation of synaptic transmission T cell receptor signaling pathway release of sequestered calcium ion into cytosol positive regulation of release of sequestered calcium ion into cytosol cellular response to epidermal growth factor stimulus positive regulation of wound healing regulation of store-operated calcium channel activity response to curcumin positive regulation of vascular endothelial cell proliferation positive regulation of endothelial cell apoptotic process negative regulation of inflammatory response to antigenic stimulus Fc-epsilon receptor signaling pathway antigen receptor-mediated signaling pathway
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