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Invitrogen
SLC22A12 Polyclonal Antibody
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Product Details
PA5-106386
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SLC22A12(Accession Q96S37), corresponding to amino acid residues D55-A105.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total URAT1.
Target Information
SLC22A12 is required for efficient urate re-absorption in the kidney. SLC22A12 regulates blood urate levels. SLC22A12 mediates saturable urate uptake by facilitating the exchange of urate against organic anions.The protein encoded by this gene is a urate transporter and urate-anion exchanger which regulates the level of urate in the blood. This protein is an integral membrane protein primarily found in kidney. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Organic anion transporter 4-like protein; Renal-specific transporter; RST; solute carrier family 22 (organic anion/cation transporter), member 12; solute carrier family 22 (organic anion/urate transporter), member 12; solute carrier family 22 (organic cation transporter)-like 2; Solute carrier family 22 member 12; unnamed protein product; URAT1; Urate anion exchanger 1; urate anion transporter 1; urate transporter 1; Urate:anion antiporter SLC22A12
Gene Aliases: AI987855; hURAT1; OAT4L; OATL4; RST; SLC22A12; Slc22al2; UAT; UNQ6453/PRO34004; URAT1
UniProt ID: (Human) Q96S37, (Rat) Q3ZAV1, (Mouse) Q8CFZ5
Entrez Gene ID: (Human) 116085, (Rat) 365398, (Mouse) 20521
ion transport
response to xenobiotic stimulus
organic anion transport
urate transport
cellular homeostasis
cellular response to insulin stimulus
urate metabolic process
transmembrane transport
urate salt excretion
biological_process
organic acid transport
response to drug
transport
organic acid transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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