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Invitrogen
CYP11B1/CYP11B2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-106795
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CYP11B1(Accession P15538), corresponding to amino acid residues K6-T26.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total Cytochrome P450 11B1/2.
靶标信息
The steroid 11beta-hydroxylase gene, also designated Cyp11b-1, is a marker for the functional differentiation of cells in the zonae fasciculata reticularis. The deduced protein CYP11B1 consists of 466 amino acids containing a secretory signal, epidermal growth factor-like repeats, and a proteolytically inactive cathepsin B-related sequence. A related protein, human aldosterone synthase (CYP11B2), is involved in substrate recognition and conversion, with a functionally significant residue 112 in the N-terminal region of human CYP11B2. The inherited disorder glucocorticoid-remediable aldosteronism is caused by a chimeric gene duplication between the CYP11B1 and CYP11B2 genes. This disorder is characterized by hyperaldosteronism and high levels of 18-hydroxycortisol and 18-oxocortisol, which are under ACTH control.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; Corticosterone 18-monooxygenase, CYP11B2; CYP11B1; CYP11B1-V316M; CYPXIB1; CYPXIB2; Cytochrome P-450Aldo; Cytochrome P-450c11; Cytochrome P-450C18; Cytochrome P450 11B1, mitochondrial; Cytochrome P450 11B2, mitochondrial; cytochrome p450 XIB1; cytochrome P450, family 11, subfamily B, polypeptide 1; cytochrome P450, family 11, subfamily B, polypeptide 2; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2; Cytochrome P450C11; mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2; Steroid 11-beta-hydroxylase, CYP11B1; Steroid 11-beta-hydroxylase, CYP11B2; steroid 11-beta-monooxygenase; steroid 11-beta/18-hydroxylase; Steroid 18-hydroxylase; steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo; unnamed protein product
基因别名: ALDOS; CPN1; CPN2; CYP11B; CYP11B1; CYP11B2; CYP11BL; CYPXIB2; FHI; P-450C18; P450aldo; P450C11; P450C18; S11BH
Entrez Gene ID: (Human) 1584, (Human) 1585
C21-steroid hormone biosynthetic process
glucocorticoid biosynthetic process
immune response
cholesterol metabolic process
regulation of blood pressure
sterol metabolic process
aldosterone biosynthetic process
cellular response to hormone stimulus
cortisol metabolic process
cortisol biosynthetic process
cellular response to potassium ion
glucose homeostasis
cellular response to peptide hormone stimulus
regulation of blood volume by renal aldosterone
renal water homeostasis
mineralocorticoid biosynthetic process
potassium ion homeostasis
sodium ion homeostasis
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