Search
Invitrogen
STAR Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 3
STAR Antibody (PA5-106859) in IHC (P)
Immunohistochemistry analysis of STAR in mouse kidney tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with STAR polyclonal antibody (Product # PA5-106859) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-106859
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Avian,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human STAR(Accession P49675), corresponding to amino acid residues Q158-N208.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total STAR.
Target Information
Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane. The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone. StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue. Abnormalities in StAR gene expression are impacted in autosomal Lipoid Congenial Adrenal Hyperplasia (LCAH) resulting in defects in pregnenolone and cortisol synthesis. The mechanism of cholesterol binding to StAR has yet to be elucidated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Luteinizing hormone-induced protein; StAR; StARD1; START domain-containing protein 1; Steroidogenic acute regulatory protein, mitochondrial
Gene Aliases: AV363654; D8Ertd419e; STAR; STARD1
UniProt ID: (Mouse) P51557, (Rat) P97826
Entrez Gene ID: (Mouse) 20845, (Rat) 25557
steroid biosynthetic process
bile acid biosynthetic process
estrogen biosynthetic process
transport
lipid transport
glucocorticoid metabolic process
positive regulation of gene expression
cellular response to interferon-alpha
negative regulation of neuron apoptotic process
cellular lipid metabolic process
regulation of neuronal synaptic plasticity
positive regulation of neurogenesis
regulation of steroid biosynthetic process
organic acid metabolic process
progesterone biosynthetic process
brain development
response to nutrient
circadian rhythm
cholesterol metabolic process
male gonad development
response to herbicide
response to toxic substance
response to organic substance
response to ionizing radiation
response to lead ion
response to organic cyclic compound
response to activity
diterpenoid metabolic process
response to insecticide
insecticide metabolic process
biphenyl metabolic process
dibenzo-p-dioxin metabolic process
phenol-containing compound metabolic process
phthalate metabolic process
response to nutrient levels
intracellular cholesterol transport
cellular response to insulin stimulus
response to gonadotropin
response to nicotine
response to drug
response to hydrogen peroxide
circadian sleep/wake cycle, REM sleep
response to peptide hormone
response to estrogen
response to leptin
cellular response to fibroblast growth factor stimulus
response to ethanol
response to antibiotic
response to steroid hormone
response to corticosterone
response to fungicide
testosterone biosynthetic process
cellular response to lipopolysaccharide
cellular response to antibiotic
cellular response to metal ion
cellular response to cadmium ion
cellular response to alkaloid
cellular response to cAMP
cellular response to glucose stimulus
cellular response to interferon-gamma
cellular response to gonadotropin stimulus
cellular response to follicle-stimulating hormone stimulus
cellular response to luteinizing hormone stimulus
cellular response to growth hormone stimulus
cellular response to organic cyclic compound
cellular response to dexamethasone stimulus
cellular response to transforming growth factor beta stimulus
cellular response to epinephrine stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support