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Invitrogen
NCF2 Polyclonal Antibody
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图: 1 / 4
NCF2 Antibody (PA5-106873) in IHC (P)
Immunohistochemistry analysis of NCF2 in mouse liver tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with NCF2 polyclonal antibody (Product # PA5-106873) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-106873
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NCF2(Accession P19878), corresponding to amino acid residues A17-D67.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total NCF2.
靶标信息
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Defects in NCF2 are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 2 (CGD2). Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 67 kDa neutrophil oxidase factor; FLJ93058; NADPH oxidase activator 2; NADPH oxidase subunit (67 kD); NADPH oxidase subunit (67kDa); NCF-2; ncf2; ncf2 {ECO:0000312|EMBL:FAA00361.1}; Neutrophil cytosol factor 2; Neutrophil NADPH oxidase factor 2; p67-phox
基因别名: Ncf-2; NCF2; NOXA2; P67PHOX
UniProt ID: (Mouse) O70145
Entrez Gene ID: (Mouse) 17970, (Rat) 364018
NADP catabolic process
superoxide metabolic process
response to glucose
response to organic cyclic compound
response to lipopolysaccharide
cellular response to hormone stimulus
superoxide anion generation
positive regulation of neuron apoptotic process
positive regulation of blood pressure
aging
response to activity
response to progesterone
response to lipid
response to laminar fluid shear stress
response to drug
response to hyperoxia
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