Search
Invitrogen
UBE3C Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 1
UBE3C Antibody (PA5-110540) in WB
Journal of translational medicine 2023 -
Fig. 2 UBE3C knockdown enhances radiosensitivity of BRCA cells. A, RT-qPCR and WB analyses for mRNA ( A ) and protein ( B ) levels of UBE3C in MDA-MB-231 and SK-BR-3 cells (R and Pa) after sh-UBE3C or oe-UBE3C transfection; C sensitivity of MDA-MB-231 and SK-BR-3 cells (R and Pa) to different doses of irradiation ( 0, 2, 4, 8, and 12 Gy) analyzed by the CTG kit; D , number of colonies formed by R or Pa BRCA... View More
Product Details
PA5-110540
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 970-1083 of human UBE3C (NP_0554862)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.81 mg/mL
Amount
81 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PISLEDLKSF TNYSGGYSAD HPVIKVFWRV VEGFTDEEKR KLLKFVTSCS RPPLLGFKEL YPAFCIHNGG SDLERLPTAS TCMNLLKLPE FYDETLLRSK LLYAIECAAG FELS
Product note: Prior to December 2023, PA5-110540 was manufactured using a Recombinant fusion protein immunogen containing a sequence corresponding to amino acids 1-270 of human UBE3C. The affected lots are: WE3272737, WL3440149, XG3626363, 334B8A30, WH3338145, and VE2999302. Beginning in January 2024, all lots have been produced using a Recombinant fusion protein immunogen containing a sequence corresponding to amino acids 970-1083 of human UBE3C. Refer to the datasheets linked below for lot-specific immunogen information.
Target Information
E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HECT-type ubiquitin transferase E3C; HectH2; Homologous to E6AP carboxyl terminus homologous protein 2; KIAA0010; RAUL; RTA-associated ubiquitin ligase; ubiquitin-protein isopeptide ligase (E3); Ubiquitin-protein ligase E3C; unnamed protein product
Gene Aliases: HECTH2; KIAA0010; KIAA10; NDSMBA; NEDSMBA; RAUL; UBE3C
UniProt ID: (Human) Q15386
Entrez Gene ID: (Human) 9690
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support