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Invitrogen
USP22 Polyclonal Antibody
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USP22 Antibody (PA5-110558) in WB
Western blot analysis of USP22 in extracts of various cell lines. Samples were incubated with USP22 Polyclonal antibody (Product # PA5-110558) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-110558
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human USP22 (NP_0560911)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.59 mg/mL
规格
159 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: TAEARKRKAK SCICHVCGVH LNRLHSCLYC VFFGCFTKKH IHEHAKAKRH NLAIDLMYGG IYCFLCQDYI YDKDMEIIAK EEQRKAWKMQ GVGEKFSTWE P
靶标信息
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Deubiquitinating enzyme 22; Ubiquitin carboxyl-terminal hydrolase 22; ubiquitin specific protease 22; Ubiquitin thioesterase 22; Ubiquitin-specific-processing protease 22
基因别名: KIAA1063; USP22; USP3L
Entrez Gene ID: (Rat) 303201
molecular_function
transcription coactivator activity
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
zinc ion binding
H4 histone acetyltransferase activity
enzyme binding
ligand-dependent nuclear receptor transcription coactivator activity
cysteine protease
regulation of transcription, DNA-templated
biological_process
histone ubiquitination
histone deubiquitination
protein deubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
histone H4 acetylation
positive regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle
regulation of proteasomal protein catabolic process
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