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Invitrogen
Phospho-DNMT1 (Ser714) Polyclonal Antibody
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Phospho-DNMT1 (Ser714) Antibody (PA5-114568) in ICC/IF
Immunocytochemistry analysis of Phospho-DNMT1 (Ser714) in HeLa cells (heat shock treatment). Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-114568). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conju... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-114568
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human Dnmt1 around the phosphorylation site of Ser714.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
sequential chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of Dnmt1 only when phosphorylated at Ser714.
靶标信息
This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CXXC-type zinc finger protein 9; DNA (cytosine-5)-methyltransferase 1; DNA methyltransferase HsaI; DNA methyltransferase MmuI; DNA MTase HsaI; DNA MTase MmuI; Dnmt1; FLJ16293; MCMT; MGC104992
基因别名: AIM; CXXC9; DNMT; DNMT1; Dnmt1o; m.MmuI; MCMT; Met-1; Met1; MommeD2; MTase; Uim
UniProt ID: (Mouse) P13864
Entrez Gene ID: (Mouse) 13433
DNA binding
chromatin binding
double-stranded DNA binding
RNA binding
catalytic activity
DNA (cytosine-5-)-methyltransferase activity
protein binding
transcription factor binding
methyltransferase activity
zinc ion binding
methyl-CpG binding
DNA-methyltransferase activity
transferase activity
protein domain specific binding
estrogen receptor binding
histone deacetylase binding
unmethylated CpG binding
metal ion binding
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
DNA metabolism protein
DNA methyltransferase
nucleic acid metabolism protein
negative regulation of transcription from RNA polymerase II promoter
DNA methylation
transcription, DNA-templated
regulation of transcription, DNA-templated
metabolic process
maintenance of DNA methylation
DNA methylation on cytosine within a CG sequence
regulation of gene expression
positive regulation of gene expression
gene silencing
chromatin modification
methylation
DNA methylation on cytosine
response to antidepressant
regulation of cell proliferation
DNA hypermethylation
negative regulation of transcription, DNA-templated
S-adenosylhomocysteine metabolic process
S-adenosylmethioninamine metabolic process
S-adenosylmethionine metabolic process
positive regulation of histone H3-K4 methylation
negative regulation of histone H3-K9 methylation
cellular response to amino acid stimulus
cellular response to transforming growth factor beta stimulus
C-5 methylation of cytosine
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