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Invitrogen

MRP1 Polyclonal Antibody

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View all (23) MRP1 antibodies

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MRP1 Polyclonal Antibody

Product Details

PA5-114802

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-

Immunocytochemistry (ICC/IF)

1:100
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ABCC1(Accession P33527), corresponding to amino acid residues M1-V39.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2899438

Product Specific Information

Antibody detects endogenous levels of total ABCC1.

Target Information

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ABC-transporter; MRP; ABCC1; ATP-binding cassette sub-family C ( CFTR/MRP) member 1a; ATP-binding cassette sub-family C member 1; ATP-binding cassette transporter variant ABCC1delta-ex13&14; ATP-binding cassette transporter variant ABCC1delta-ex25&26; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1a; ATP-binding cassette, sub-family C (CFTR/MRP), member 1b; ATP-binding cassette, sub-family C, member 1-like; ATP-binding cassette, subfamily C (CFTR/MRP), member 1; DKFZp686N04233; DKFZp781G125; glutathione S-conjugate export pump; glutathione-S-conjugate-translocating ATPase ABCC1; leuk; leukotriene C(4) transporter; LTC4 transporter; multidrug resistance protein 1; multidrug resistance-associated protein 1-like; multiple drug resistance-associated protein; unnamed protein product

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Gene Aliases: ABC29; ABCC; Abcc1a; Abcc1b; Avcc1a; DFNA77; GS-X; Mdrap; MRP; MRP1

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UniProt ID: (Human) P33527, (Rat) Q8CG09, (Mouse) O35379

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Entrez Gene ID: (Human) 4363, (Rat) 24565, (Mouse) 17250

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Function(s)
ATP binding xenobiotic-transporting ATPase activity cobalamin-transporting ATPase activity glutathione S-conjugate-exporting ATPase activity efflux transmembrane transporter activity ATPase activity transmembrane transporter activity lipid-transporting ATPase activity glutathione transmembrane transporter activity ATPase activity, coupled to transmembrane movement of substances xenobiotic transporter activity carboxylic acid transmembrane transporter activity ABC-type transporter activity long-chain fatty acid transporter activity oxidoreductase activity
Process(es)
tissue homeostasis granuloma formation inflammatory response to antigenic stimulus endothelium development leukotriene metabolic process glutathione metabolic process lipid transport apoptotic process inflammatory response immune response cellular response to DNA damage stimulus response to oxidative stress memory glucocorticoid metabolic process response to xenobiotic stimulus response to toxic substance glial cell differentiation gene expression monocarboxylic acid transport bilirubin transport cobalamin transport plasma membrane long-chain fatty acid transport leukotriene biosynthetic process amygdala development hippocampus development neurogenesis positive regulation of cell migration phospholipid efflux response to interferon-gamma protein localization to cell surface response to fluid shear stress glutathione transport glutathione transmembrane transport multicellular organism growth exploration behavior macrophage activation vasodilation regulation of membrane potential superoxide anion generation xenobiotic transport pigment accumulation fibroblast apoptotic process phospholipid translocation cell redox homeostasis tetrahydrobiopterin metabolic process antigen processing and presentation of lipid antigen via MHC class Ib astrocyte differentiation beta-amyloid metabolic process hydrogen peroxide biosynthetic process positive regulation of inflammatory response regulation of catalytic activity defense response to Gram-positive bacterium NK T cell activation response to glucocorticoid cellular chemical homeostasis transmembrane transport cell chemotaxis transepithelial transport cyclic nucleotide transport cellular response to interferon-gamma leukotriene transport endothelial cell apoptotic process lymphocyte migration beta-amyloid clearance neural tissue regeneration regulation of blood vessel diameter sphingolipid translocation export across plasma membrane export from cell intracellular nitrogen homeostasis reactive oxygen species biosynthetic process cellular response to beta-amyloid carboxylic acid transmembrane transport drug transmembrane export drug transport across blood-brain barrier regulation of cellular response to drug drug transmembrane transport xenobiotic metabolic process sphingolipid biosynthetic process cellular response to oxidative stress heme catabolic process carboxylic acid transport transport across blood-brain barrier
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