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Invitrogen

ABL1/ABL2 Polyclonal Antibody

View all (6) ABL1/ABL2 antibodies

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ABL1/ABL2 Polyclonal Antibody

Product Details

PA5-114805

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ABL1(Accession P00519), corresponding to amino acid residues R367-S417.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2899441

Product Specific Information

Antibody detects endogenous levels of total ABL1/2.

Target Information

The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblastic leukemia (ALL) and 2-5% of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Abelson murine leukemia oncogene; Abelson murine leukemia viral oncogene homolog 1; Abelson murine leukemia viral oncogene homolog 2; Abelson tyrosine-protein kinase 1; Abelson tyrosine-protein kinase 2; Abelson-related gene protein; abl2; c-abl oncogene 1, receptor tyrosine kinase; p150; Proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; tyrosine kinase ARG; Tyrosine-protein kinase ABL1; Tyrosine-protein kinase ABL2; Tyrosine-protein kinase ARG; v-abl Abelson murine leukemia oncogene 1; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

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Gene Aliases: AA536808; ABL; ABL1; ABL2; ABLL; AI325092; ARG; c-Abl; E430008G22Rik; JTK7

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UniProt ID: (Mouse) P00520

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Entrez Gene ID: (Mouse) 11350, (Mouse) 11352

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Function(s)
nucleotide binding magnesium ion binding DNA binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding protein binding ATP binding protein C-terminus binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups SH3 domain binding protein kinase binding protein domain specific binding syntaxin binding manganese ion binding metal ion binding actin filament binding mitogen-activated protein kinase binding proline-rich region binding delta-catenin binding
Process(es)
B-1 B cell homeostasis positive regulation of protein phosphorylation B cell proliferation involved in immune response transitional one stage B cell differentiation DNA repair protein phosphorylation endocytosis phagocytosis autophagy apoptotic process cellular response to DNA damage stimulus DNA damage induced protein phosphorylation response to oxidative stress cell adhesion epidermal growth factor receptor signaling pathway positive regulation of cytosolic calcium ion concentration phosphorylation cell migration peptidyl-tyrosine phosphorylation cerebellum morphogenesis negative regulation of cell-cell adhesion microspike assembly actin cytoskeleton organization negative regulation of BMP signaling pathway regulation of actin cytoskeleton organization positive regulation of osteoblast proliferation substrate adhesion-dependent cell spreading peptidyl-tyrosine autophosphorylation B cell proliferation signal transduction in response to DNA damage positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling innate immune response negative regulation of mitotic cell cycle positive regulation of mitotic cell cycle alpha-beta T cell differentiation platelet-derived growth factor receptor signaling pathway spleen development thymus development collateral sprouting positive regulation of peptidyl-tyrosine phosphorylation activated T cell proliferation B cell receptor signaling pathway neuromuscular process controlling balance positive regulation of release of sequestered calcium ion into cytosol positive regulation of oxidoreductase activity negative regulation of ubiquitin-protein transferase activity regulation of cell cycle Bergmann glial cell differentiation negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide negative regulation of protein serine/threonine kinase activity actin filament branching positive regulation of interleukin-2 secretion negative regulation of phospholipase C activity positive regulation of neuron death positive regulation of interferon-gamma secretion regulation of extracellular matrix organization positive regulation of Wnt signaling pathway, planar cell polarity pathway negative regulation of endothelial cell apoptotic process regulation of cellular senescence negative regulation of cellular senescence regulation of response to DNA damage stimulus substrate-dependent cell migration, cell extension actin filament organization learning visual learning positive regulation of phospholipase C activity positive regulation of neuron projection development neuron remodeling positive regulation of protein binding cellular protein localization negative regulation of Rho protein signal transduction exploration behavior regulation of cell proliferation dendrite morphogenesis actin filament bundle assembly cellular response to retinoic acid dendritic spine maintenance
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