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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Antibody detects endogenous levels of total Bestrophin 2.
Best2 forms calcium-sensitive chloride channels and is permeable to bicarbonate. The Best2 gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in the Best2 gene is associated with vitelliform macular dystrophy. The Best2 gene is mainly expressed in the retinal pigment epithelium and colon. Diseases associated with BEST2 include Vitelliform Macular Dystrophy and Bestrophinopathy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Bestrophin-2; Bestrophin-2a; Hbest2; Vitelliform macular dystrophy 2-like protein 1; VMD2L-1
基因别名: BEST2; VMD2L1
UniProt ID: (Mouse) Q8BGM5
Entrez Gene ID: (Rat) 364973, (Mouse) 212989