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Invitrogen
DAPK1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-115092
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human DAPK1(Accession P53355), corresponding to amino acid residues L284-D334.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total DAPK1.
靶标信息
DAPK1 is a large, calmodulin-dependent kinase involved in gamma-interferon induced programmed cell death and is a potential tumor suppressor. DAPK1 is involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and authophagy. It regulates both type I apoptotic and type II autophagic cell death signal, depending on the cellular setting. Type I apoptotic cell death is caspase-dependent, type II authophagic cell death is caspase-independent. DAPK1 phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. It also phosphorylates TPM1, STX1A, PRKD1, BECN1, TSC2, RPS6, MYL9, and DAPK3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DAP kinase 1; Death-associated protein kinase 1; DKFZp781I035; OTTHUMP00000216193
基因别名: D13Ucla1; DAP-Kinase; DAPK; DAPK1
UniProt ID: (Mouse) Q80YE7
Entrez Gene ID: (Rat) 306722, (Mouse) 69635
protein kinase activity
calmodulin-dependent protein kinase activity
calmodulin binding
ATP binding
syntaxin-1 binding
identical protein binding
nucleotide binding
protein serine/threonine kinase activity
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein phosphorylation
apoptotic process
extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of translation
intracellular signal transduction
regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein autophosphorylation
cellular response to interferon-gamma
apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of N-methyl-D-aspartate selective glutamate receptor activity
regulation of translation
signal transduction
phosphorylation
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
