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Invitrogen
GM2A Polyclonal Antibody
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图: 1 / 5
GM2A Antibody (PA5-115302) in ICC/IF
Immunocytochemistry analysis of GM2A in HepG2 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115302). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-115302
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human GM2A(Accession P17900), corresponding to amino acid residues I119-R169.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total GM2A.
靶标信息
This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cerebroside sulfate activator protein; Ganglioside GM2 activator; GM2 ganglioside activator protein; GM2-AP; SAP-3; shingolipid activator protein 3; Sphingolipid activator protein 3
基因别名: AA408702; AW215435; GM2-AP; GM2A; SAP-3
UniProt ID: (Mouse) Q60648
Entrez Gene ID: (Mouse) 14667, (Rat) 282838
lipid metabolic process
sphingolipid metabolic process
ganglioside catabolic process
learning or memory
oligosaccharide catabolic process
lipid storage
positive regulation of catalytic activity
neurological system process
neuromuscular process controlling balance
ganglioside metabolic process
lipid transport
positive regulation of hydrolase activity
membrane fusion
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