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Invitrogen
GZMB/GZMH Polyclonal Antibody
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GZMB/GZMH Antibody (PA5-115323) in IHC (P)
Immunohistochemistry analysis of GZMB/GZMH in human normal tissues adjacent to pancreatic cancer. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115323) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-115323
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human GZMB(Accession P10144), corresponding to amino acid residues M1-G50.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total Granzyme B/H.
靶标信息
GZMB/GZMH are members of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C11; Cathepsin G-like 1; Cathepsin G-like 2; CCP-X; CCP1; CGL-2; CGL2; CSP-C; CTLA-1; CTLA1; CTSGL1; CTSGL2; Cytotoxic cell protease 1; Cytotoxic serine protease C; Cytotoxic T-lymphocyte proteinase; Cytotoxic T-lymphocyte proteinase 2; Fragmentin; Fragmentin-2; GLP I; GLP III; GLP-1; Granzyme B; Granzyme B(G,H); Granzyme H; Granzyme-2; granzyme-like protein 1; granzyme-like protein I; GZMH; GZMH/GZMB; HLP; Human lymphocyte protein; Lymphocyte protease; Natural killer cell protease 1; RNKP-1; SECT; T-cell serine protease 1-3E
基因别名: AI553453; CCP-1/C11; CCP1; CGL1; CGL2; CSPB; Ctla-1; CTLA1; CTSGL2; GRB; GZB; GZMB; GZMH; RNKP-1
UniProt ID: (Mouse) P04187, (Rat) P18291
Entrez Gene ID: (Mouse) 14939, (Rat) 171528
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