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Invitrogen
ITSN1 Polyclonal Antibody
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图: 1 / 3
ITSN1 Antibody (PA5-115432) in ICC/IF
Immunocytochemistry analysis of ITSN1 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115432) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-115432
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ITSN1(Accession Q15811), corresponding to amino acid residues L274-S324.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total Intersectin 1.
靶标信息
The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EH and SH3 domains protein 1; EH domain and SH3 domain regulator of endocytosis 1; Eh domain, SH3 domain regulator of endocytosis 1; intersectin (SH3 domain protein 1A); intersectin 1 (SH3 domain protein 1A); intersectin short form 2 variant 2; Intersectin-1; intersectin-L; MGC134948; MGC134949; SH3 domain-containing protein 1A; SH3P17
基因别名: AA517634; AA545208; AI316805; AI839402; AI848451; Ehsh1; Ese1; ITSN; ITSN1; SH3D1A; Sh3p17
UniProt ID: (Mouse) Q9Z0R4, (Rat) Q9WVE9
Entrez Gene ID: (Mouse) 16443, (Rat) 29491
endocytosis
small GTPase mediated signal transduction
regulation of Rho protein signal transduction
intracellular signal transduction
positive regulation of phosphorylation
positive regulation of catalytic activity
negative regulation of neuron apoptotic process
positive regulation of protein kinase B signaling
exocytosis
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