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Invitrogen
Nkx2.2 Polyclonal Antibody
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图: 1 / 2
Nkx2.2 Antibody (PA5-115656) in ICC/IF
Immunocytochemistry analysis of Nkx2.2 in HepG2 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115656) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-115656
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NKX2-2(Accession O95096), corresponding to amino acid residues H88-A138.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total NKX22.
靶标信息
The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Drosophila NK2 transcription factor related, locus 2; glycoprotein GP330, renal; Homeobox protein NK-2 homolog B; Homeobox protein Nkx-2.2; homeobox protein Nkx2-2; NK2 transcription factor related, locus 2; Nkx2.2
基因别名: Nkx-2.2; NKX2-2; NKX2.2; NKX2B; tinman
UniProt ID: (Mouse) P42586
Entrez Gene ID: (Rat) 366214, (Mouse) 18088
RNA polymerase II distal enhancer sequence-specific DNA binding
core promoter proximal region DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
molecular_function
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription factor binding
sequence-specific DNA binding
DNA binding
protein binding
homeodomain transcription factor
type B pancreatic cell development
pancreatic A cell fate commitment
type B pancreatic cell fate commitment
pancreatic PP cell fate commitment
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
smoothened signaling pathway
nervous system development
response to glucose
positive regulation of gene expression
oligodendrocyte development
response to organic cyclic compound
spinal cord motor neuron differentiation
spinal cord oligodendrocyte cell differentiation
spinal cord oligodendrocyte cell fate specification
optic nerve development
cell differentiation
endocrine pancreas development
response to progesterone
regulation of cell differentiation
positive regulation of cell differentiation
negative regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
cell development
digestive tract development
neuron fate specification
astrocyte differentiation
positive regulation of oligodendrocyte differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
ventral spinal cord interneuron fate determination
transcription, DNA-templated
multicellular organism development
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