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Invitrogen
PLXNA4 Polyclonal Antibody
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FIGURE: 1 / 4
PLXNA4 Antibody (PA5-115772) in ICC/IF
Immunocytochemistry analysis of PLXNA4 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115772) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115772
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PLXNA4(Accession Q9HCM2), corresponding to amino acid residues A1849-S1894.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Plexin A4.
Target Information
PLXNA4 is a protein coding gene. Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: OTTHUMP00000207245; Plexin-A4
Gene Aliases: 9330117B14; KIAA1550; mKIAA1550; Plxa4; PLXNA4; PLXNA4A; PLXNA4B; UNQ2820/PRO34003
UniProt ID: (Mouse) Q80UG2
Entrez Gene ID: (Mouse) 243743, (Rat) 312213
nervous system development
axon guidance
cranial nerve morphogenesis
facial nerve morphogenesis
facial nerve structural organization
glossopharyngeal nerve morphogenesis
trigeminal nerve morphogenesis
trigeminal nerve structural organization
vagus nerve morphogenesis
postganglionic parasympathetic fiber development
chemorepulsion of branchiomotor axon
anterior commissure morphogenesis
sympathetic nervous system development
neuron projection morphogenesis
regulation of axon extension involved in axon guidance
regulation of negative chemotaxis
semaphorin-plexin signaling pathway
semaphorin-plexin signaling pathway involved in axon guidance
signal transduction
motor neuron axon guidance
branchiomotor neuron axon guidance
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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