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Invitrogen
PEDF Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-115885
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SERPINF1(Accession P36955), corresponding to amino acid residues V325-P375.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total SERPINF1.
靶标信息
PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors, such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity (1) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature-related neurodegenerative diseases, such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha-2 antiplasmin; Caspin; Cell proliferation-inducing gene 35 protein; EPC 1; EPC-1; EPC1; PEDF; PIG 35; pigment epithelium derived factor; Pigment epithelium-derived factor; SDF-3; serine (or cysteine) peptidase inhibitor, clade F, member 1; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; serine (or cysteine) proteinase inhibitor, clade F), member 1; serine (or cysteine) proteinase inhibitor, clade F, member 1; Serpin F1; serpin-F1; SERPINF 1; stromal cell derived factor 3; Stromal cell-derived factor 3
基因别名: AI195227; Dmrs91; EPC-1; PEDF; Pedfl; PIG35; Sdf3; SERPINF1
UniProt ID: (Mouse) P97298
Entrez Gene ID: (Mouse) 20317, (Rat) 287526
short-term memory
negative regulation of endothelial cell migration
negative regulation of gene expression
negative regulation of endopeptidase activity
positive regulation of neuron projection development
negative regulation of angiogenesis
negative regulation of inflammatory response
positive regulation of neurogenesis
negative regulation of epithelial cell proliferation involved in prostate gland development
negative regulation of neuron death
kidney development
aging
response to acidic pH
ovulation cycle
response to arsenic-containing substance
retina development in camera-type eye
cellular response to cobalt ion
cellular response to retinoic acid
cellular response to glucose stimulus
cellular response to dexamethasone stimulus
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