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Invitrogen
TCF21 Polyclonal Antibody
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图: 1 / 2
TCF21 Antibody (PA5-116012) in ICC/IF
Immunocytochemistry analysis of TCF21 in A549 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-116012). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-116012
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human TCF21(Accession O43680), corresponding to amino acid residues C20-S70.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total TCF21.
靶标信息
The basic helix-loop-helix transcription factor TCF21/Pod1 (also called capsulin or epicardin) is involved in kidney, lung and spleen organogenesis. It is also essential for normal development of the testes and ovaries. TCF21/Pod1 is involved in the transcriptional repression of steroidogenic factor 1 (Sf1/Nr5a1/Ad4BP), an orphan nuclear receptor that regulates the expression of multiple genes (including Scc) that mediate sexual differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: bHLHa23; Capsulin; Class A basic helix-loop-helix protein 23; Epicardin; Pod-1; Podocyte-expressed 1; TCF-21; Transcription factor 21
基因别名: BHLHA23; Capsulin; epc; epicardin; Msf-1; Pod-1; POD1; TCF21
UniProt ID: (Mouse) O35437
Entrez Gene ID: (Rat) 252856, (Mouse) 21412
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
histone deacetylase binding
bHLH transcription factor binding
protein dimerization activity
androgen receptor binding
E-box binding
DNA binding
protein binding
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
branching involved in ureteric bud morphogenesis
morphogenesis of a branching structure
kidney development
vasculature development
sex determination
sex differentiation
organ morphogenesis
branchiomeric skeletal muscle development
epithelial cell differentiation
glomerulus development
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
spleen development
embryonic digestive tract morphogenesis
reproductive structure development
gland development
Sertoli cell differentiation
palate development
lung morphogenesis
lung vasculature development
bronchiole development
diaphragm development
respiratory system development
negative regulation of androgen receptor signaling pathway
metanephric mesenchymal cell differentiation
metanephric glomerular capillary formation
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
regulation of histone deacetylation
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