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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
MAPK8 (JNK1) is activated by the presence of misfolded proteins in the endoplasmic reticulum. It is also a crucial mediator of insulin resistance and obesity. It belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK pathways are activated by stress and inflammatory signals. JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1 and JNK2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: c-Jun N-terminal kinase 1; FLJ12099; FLJ33785; JNK-46; MAP kinase 8; MAPK 8; MGC50974; Mitogen-activated protein kinase 8; OTTHUMP00000019552; p493F12; p54bSAPK; protein kinase JNK1; SAPK1c; Stress-activated protein kinase 1c; Stress-activated protein kinase JNK1
基因别名: JNK; JNK1; jnk1a-1; MAPK8; PRKM8; SAPK1; SAPK1C; zgc:112379
UniProt ID: (Zebrafish) Q9DGD9
Entrez Gene ID: (Zebrafish) 65236