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Invitrogen
FAT4 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-116735
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 4900-4981 of human FAT4 (NP_0788584)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.58 mg/mL
规格
158 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: U-87MG
Immunogen sequence: GGPVGTQAAA PGTADNTLPM KLGQQAGTFN WDNLLNWGPG FGHYVDVFKD LASLPEKAAA NEEGKAGTTK PVPKDGEAEQ YV
靶标信息
FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT4 undergo the first proteolytic cleavage by Furin and are predicted to undergo the second cleavage by secretase to release intracellular domain (ICD). FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane associated guanylate kinase MPP5/PALS1. FAT4 is involved in the maintenance of PCP and inhibition of cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Cadherin family member 14; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; hFat4; Protocadherin Fat 4
基因别名: 6030410K14Rik; 9430004M15; CDHF14; FAT4; FATJ; Nbla00548; RGD1564291
UniProt ID: (Mouse) Q2PZL6
Entrez Gene ID: (Rat) 310341, (Mouse) 329628
branching involved in ureteric bud morphogenesis
kidney development
heart morphogenesis
plasma membrane organization
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
cerebral cortex development
neurogenesis
hippo signaling
ossification involved in bone maturation
digestive tract development
inner ear receptor stereocilium organization
regulation of metanephric nephron tubule epithelial cell differentiation
establishment of planar polarity
cell adhesion
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
