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Invitrogen
BAIAP2 Polyclonal Antibody
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BAIAP2 Antibody (PA5-117010) in WB
Western blot analysis of BAIAP2 in extracts of various cell lines. Samples were incubated with BAIAP2 Polyclonal antibody (Product # PA5-117010) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-117010
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 362-521 of human BAIAP2 (NP_0593441)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.97 mg/mL
规格
97 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: A-549, K-562, SW620, 293T
Immunogen sequence: PRSSSMAAGL ERNGRMRVKA IFSHAAGDNS TLLSFKEGDL ITLLVPEARD GWHYGESEKT KMRGWFPFSY TRVLDSDGSD RLHMSLQQGK SSSTGNLLDK DDLAIPPPDY GAASRAFPAQ TASGFKQRPY SVAVPAFSQG LDDYGARSMS SGSGTLVSTV
靶标信息
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BAI-associated protein 2; BAI1-associated protein 2; BAR/IMD domain-containing adapter protein 2; Brain-specific angiogenesis inhibitor 1-associated protein 2; Fas ligand-associated factor 3; FLAF3; insulin receptor substrate 53; insulin receptor substrate p53; Insulin receptor substrate p53/p58; Insulin receptor substrate protein of 53 kDa; Insulin receptor tyrosine kinase 53 kDa substrate; Insulin receptor tyrosine kinase substrate protein p53; IRS-58; IRSp53
基因别名: BAIAP2; IRSp53; R75030
UniProt ID: (Mouse) Q8BKX1, (Rat) Q6GMN2
Entrez Gene ID: (Mouse) 108100, (Rat) 117542
plasma membrane organization
Rho protein signal transduction
insulin receptor signaling pathway
regulation of cell shape
response to bacterium
dendrite development
positive regulation of actin filament polymerization
regulation of actin cytoskeleton organization
regulation of synaptic plasticity
actin filament bundle assembly
actin crosslink formation
positive regulation of dendritic spine morphogenesis
positive regulation of actin cytoskeleton reorganization
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