Search
Invitrogen
Phospho-VEGF Receptor 2 (Tyr1175) Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 1
Phospho-VEGF Receptor 2 (Tyr1175) Antibody (PA5-117193) in WB
Western blot analysis of Phospho-VEGF Receptor 2 (Tyr1175) in A-431 cells. Samples were incubated with Phospho-VEGF Receptor 2 (Tyr1175) Polyclonal antibody (Product # PA5-117193) using a dilution of 1:500, followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. A-431 cells were treated by EGF (100 ng/mL) at 37°C for 30 minutes after serum-starvation overnight. Lysates/prote... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-117193
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.20 mg/mL
Amount
120 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: NIH/3T3
Target Information
KDR (FLK1, VEGFR2) is a type III receptor tyrosine kinase. It binds vascular endothelial growth factor with high affinity in vitro, and is expressed early in development by endothelial cell precursors. FLK1 (VEGF Receptor 2) encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of FLK1 (VEGF Receptor 2) are implicated in infantile capillary hemangiomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: CD309; CD309 antigen; Fetal liver kinase 1; FLK-1; FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); FLK1 kinase insert domain receptor (VEGF receptor 2); KDR; kinase insert domain protein receptor; Kinase insert domain receptor; Kinase NYK; Protein-tyrosine kinase receptor flk-1; sCD309; soluble CD309; soluble vascular endothelial growth factor receptor 2; soluble VEGFR 2; Vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor- 2; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; VEGF R2; VEGF receptor-2; VEGFR-2
Gene Aliases: 6130401C07; Flk-1; FLK1; KDR; Krd-1; Ly73; sVEGFR-2; VEGFR-2; VEGFR2
UniProt ID: (Rat) O08775, (Mouse) P35918
Entrez Gene ID: (Rat) 25589, (Mouse) 16542
protein tyrosine kinase activity
vascular endothelial growth factor-activated receptor activity
integrin binding
protein binding
ATP binding
growth factor binding
vascular endothelial growth factor binding
nucleotide binding
protein kinase activity
transmembrane receptor protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
angiogenesis
ovarian follicle development
vasculogenesis
response to hypoxia
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
lymph vessel development
cell migration involved in sprouting angiogenesis
positive regulation of mesenchymal cell proliferation
endocardium development
endothelium development
endochondral bone growth
positive regulation of cytosolic calcium ion concentration
aging
positive regulation of cell proliferation
regulation of cell shape
male gonad development
positive regulation of endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase signaling
cell migration
peptidyl-tyrosine phosphorylation
hemopoiesis
hyaluronan metabolic process
lung development
positive regulation of cell migration
positive regulation of BMP signaling pathway
positive regulation of TOR signaling
embryonic hemopoiesis
calcium-mediated signaling using intracellular calcium source
cellular response to vascular endothelial growth factor stimulus
peptidyl-tyrosine autophosphorylation
vascular endothelial growth factor signaling pathway
response to drug
negative regulation of apoptotic process
surfactant homeostasis
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
cell fate commitment
endothelial cell differentiation
regulation of endothelial cell differentiation
positive regulation of angiogenesis
positive regulation of vasodilation
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
positive regulation of long-term neuronal synaptic plasticity
lung alveolus development
cell maturation
branching morphogenesis of an epithelial tube
neuron projection morphogenesis
positive regulation of epithelial cell proliferation
positive regulation of neurogenesis
positive regulation of calcium-mediated signaling
positive regulation of positive chemotaxis
positive regulation of nitric-oxide synthase biosynthetic process
positive regulation of focal adhesion assembly
calcium ion homeostasis
positive regulation of ERK1 and ERK2 cascade
response to oxygen levels
regulation of hematopoietic progenitor cell differentiation
negative regulation of endothelial cell apoptotic process
positive regulation of vasculogenesis
regulation of endothelial cell proliferation
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
phosphorylation
cell differentiation
positive regulation of vascular endothelial growth factor receptor signaling pathway
blood vessel endothelial cell differentiation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support