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Invitrogen
Phospho-K-Ras (Ser89) Polyclonal Antibody
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Phospho-K-Ras (Ser89) Antibody (PA5-117257) in IHC (P)
Immunohistochemistry analysis of Phospho-K-Ras (Ser89) in paraffin-embedded mouse kidney. Samples were incubated with Phospho-K-Ras (Ser89) Polyclonal antibody (Product # PA5-117257) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-117257
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.47 mg/mL
规格
47 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: Jurkat, NIH/3T3
靶标信息
K-RAS (GTPase KRas) belongs to the Ras oncogene family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. It plays an important role in the regulation of cell proliferation and has a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner. Mutations in the gene can result in leukemia acute myelogenous, leukemia juvenile myelomonocytic, Noonan Syndrome, gastric cancer, and cardiofaciocutaneous syndrome 2.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: c-K-ras; c-K-ras2 protein; c-Ki-ras; c-Kirsten-ras proto-oncogene; cellular c-Ki-ras2; GTPase KRas; K RAS; K-Ras 2; Ki-Ras; Kirsten rat sarcoma oncogene 2, expressed; Kirsten rat sarcoma viral oncogene homologue 2 (active); p21 protein; RASK; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
基因别名: AI929937; c-Ki-ras; K-ras; Ki-ras; KRAS; Kras-2; KRAS2; p21; p21B; ras; RASK2
UniProt ID: (Rat) P08644, (Mouse) P32883
Entrez Gene ID: (Rat) 24525, (Mouse) 16653
positive regulation of protein phosphorylation
small GTPase mediated signal transduction
Ras protein signal transduction
positive regulation of cell proliferation
visual learning
positive regulation of gene expression
cytokine-mediated signaling pathway
actin cytoskeleton organization
regulation of synaptic transmission, GABAergic
positive regulation of Rac protein signal transduction
social behavior
positive regulation of MAP kinase activity
negative regulation of neuron apoptotic process
negative regulation of cell differentiation
regulation of long-term neuronal synaptic plasticity
homeostasis of number of cells within a tissue
positive regulation of nitric-oxide synthase activity
positive regulation of NF-kappaB transcription factor activity
striated muscle cell differentiation
response to glucocorticoid
response to mineralocorticoid
epithelial tube branching involved in lung morphogenesis
signal transduction
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