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Invitrogen

PKC lambda/iota Polyclonal Antibody

View all (16) PKC lambda/iota antibodies

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PKC lambda/iota Polyclonal Antibody

Product Details

PA5-118805

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PRKCI(Accession P41743), corresponding to amino acid residues A266-V316.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2903305

Product Specific Information

Antibody detects endogenous levels of total PRKCI.

Target Information

The PKC family of serine/threonine kinases, including PRKCI (PKC iota), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: aPKC-lambda/iota; Atypical protein kinase C-lambda/iota; nPKC-iota; PKC iota; PRKC-lambda/iota; Protein kinase C iota type; protein kinase C, lambda; unnamed protein product

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Gene Aliases: 2310021H13Rik; AI427505; aPKClambda; DXS1179E; mKIAA4165; nPKC-iota; PKCI; Pkcl; PKClambda; PRKCI; Prkcl

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UniProt ID: (Human) P41743, (Mouse) Q62074, (Rat) F1M7Y5

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Entrez Gene ID: (Human) 5584, (Mouse) 18759, (Rat) 84006

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity calcium-independent protein kinase C activity protein binding ATP binding phospholipid binding zinc ion binding kinase activity transferase activity metal ion binding protein serine kinase activity transferase activity, transferring phosphorus-containing groups protein domain specific binding molecular_function non-receptor serine/threonine protein kinase
Process(es)
protein phosphorylation protein targeting to membrane cytoskeleton organization actin filament organization positive regulation of neuron projection development vesicle-mediated transport cell migration establishment of cell polarity cellular response to insulin stimulus negative regulation of glial cell apoptotic process establishment of apical/basal cell polarity intracellular signal transduction eye photoreceptor cell development negative regulation of apoptotic process response to peptide hormone negative regulation of neuron apoptotic process establishment or maintenance of epithelial cell apical/basal polarity cell-cell junction organization positive regulation of Notch signaling pathway positive regulation of glucose import secretion Golgi vesicle budding positive regulation of NF-kappaB transcription factor activity positive regulation of glial cell proliferation membrane organization cellular response to chemical stress response to interleukin-1 protein localization to plasma membrane regulation of postsynaptic membrane neurotransmitter receptor levels positive regulation of protein localization to plasma membrane positive regulation of endothelial cell apoptotic process multicellular organism development phosphorylation cellular protein localization positive regulation of establishment of protein localization to plasma membrane
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