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Invitrogen

AKR1C1 Polyclonal Antibody

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AKR1C1 Polyclonal Antibody

Product Details

PA5-120192

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human AKR1C1 (NP_001344.2).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Amount

22 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2913764

Product Specific Information

Positive test controls include: HeLa, 22Rv1, U-87MG, Mouse liver. The target is usually found in the following locations: Cytoplasm.

Immunogen sequence: MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA VEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNQR KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN RNVRYLTLDI FAGPPNYPFS DEY

Target Information

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 17-beta-HSD 5; 17HSD type 5; 20-alpha-HSD; 20alpha-hydroxysteroid dehydrogenase; 3beta-hydroxysteroid 3-dehydrogenase; Aldo-keto reductase family 1 member C1; aldo-keto reductase family 1, member C1 (aldehyde reductase); Chlordecone reductase homolog HAKRC; DD1; Dihydrodiol dehydrogenase 1; Estradiol 17 beta-dehydrogenase 5; estradiol 17-beta-dehydrogenase (A-specific); HBAB; High-affinity hepatic bile acid-binding protein; hydroxysteroid 17-beta dehydrogenase 5; RP11-69D4.1

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Gene Aliases: 3alpha-HSD; AKR1C1; Akr1c6; DDH; DDH1; Hsd17b5

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UniProt ID: (Mouse) P70694

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Entrez Gene ID: (Mouse) 83702

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Function(s)
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity retinal dehydrogenase activity aldo-keto reductase (NADP) activity estradiol 17-beta-dehydrogenase activity isocitrate dehydrogenase activity mevaldate reductase activity gluconate dehydrogenase activity steroid dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor epoxide dehydrogenase activity 5-exo-hydroxycamphor dehydrogenase activity 2-hydroxytetrahydrofuran dehydrogenase activity acetoin dehydrogenase activity phenylcoumaran benzylic ether reductase activity D-xylose:NADP reductase activity L-arabinose:NADP reductase activity D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor steroid dehydrogenase activity, acting on the CH-CH group of donors (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity 3-hydroxymenthone dehydrogenase activity very long-chain-3-hydroxyacyl-CoA dehydrogenase activity dihydrotestosterone 17-beta-dehydrogenase activity (R)-2-hydroxyisocaproate dehydrogenase activity L-arabinose 1-dehydrogenase (NADP+) activity L-xylulose reductase (NAD+) activity 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity androsterone dehydrogenase activity testosterone 17-beta-dehydrogenase (NADP+) activity 3-ketoglucose-reductase activity (R)-2-hydroxyglutarate dehydrogenase activity D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity oxidoreductase reductase metabolite interconversion enzyme
Process(es)
lipid metabolic process steroid biosynthetic process steroid metabolic process response to drug response to estrogen daunorubicin metabolic process doxorubicin metabolic process negative regulation of mRNA splicing, via spliceosome oxidation-reduction process cellular response to jasmonic acid stimulus
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