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Invitrogen
MEKK4 Polyclonal Antibody
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MEKK4 Antibody (PA5-120505) in IHC (P)
Immunohistochemistry analysis of MEKK4 in paraffin-embedded human colon carcinoma. Samples were incubated with MEKK4 Polyclonal antibody (Product # PA5-120505) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-120505
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAP3K4 (NP_005913.2).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.35 mg/mL
规格
135 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: K-562, Rat brain.
Immunogen sequence: MREAAAALVP PPAFAVTPAA AMEEPPPPPP PPPPPPEPET ESEPECCLAA RQEGTLGDSA CKSPESDLED FSDETNTENL YGTSPPSTPR QMKRMSTKHQ
靶标信息
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: JNKK1; MAP three kinase 1; MAP2K4; MAPK/ERK kinase kinase 4; MEK kinase 4; Mitogen-activated protein kinase kinase kinase 4; PRKMK4; SAPK/ERK kinase 1; SERK1
基因别名: KIAA0213; MAP3K4; MAPKKK4; MEKK4; MTK1
Entrez Gene ID: (Rat) 308106
MAPK cascade
activation of MAPKK activity
activation of MAPK activity
placenta development
protein phosphorylation
biological_process
response to UV-C
regulation of gene expression
male germ-line sex determination
intracellular signal transduction
positive regulation of JUN kinase activity
chorionic trophoblast cell differentiation
positive regulation of p38MAPK cascade
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
