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Invitrogen
CSB Polyclonal Antibody
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CSB Antibody (PA5-120625) in IHC (P)
Immunohistochemistry analysis of CSB in paraffin-embedded human colon carcinoma. Samples were incubated with CSB Polyclonal antibody (Product # PA5-120625) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-120625
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.7 mg/mL
规格
70 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: 293T, A-549, Mouse thymus, Rat testis.
Immunogen sequence: LPVFMEQFSV PITMGGYSNA SPVQVKTAYK CACVLRDTIN PYLLRRMKSD VKMSLSLPDK NEQVLFCRLT DEQHKVYQNF VDSKEVYRIL NGEMQIFSGL I
靶标信息
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-dependent helicase ERCC6; Chimeric CSB-PGBD3 protein; Chimeric ERCC6-PGBD3 protein; Cockayne syndrome protein CSB; CS group B correcting; DNA excision repair protein ERCC-6; excision repair cross-complementing rodent repair deficiency, complementation group 6
基因别名: 4732403I04; C130058G22Rik; CSB; ERCC6
UniProt ID: (Mouse) F8VPZ5
Entrez Gene ID: (Rat) 306274, (Mouse) 319955
response to superoxide
DNA repair
transcription-coupled nucleotide-excision repair
base-excision repair
pyrimidine dimer repair
transcription elongation from RNA polymerase I promoter
cellular response to DNA damage stimulus
response to oxidative stress
activation of JNKK activity
activation of JUN kinase activity
biological_process
intrinsic apoptotic signaling pathway in response to DNA damage
response to UV
response to toxic substance
response to X-ray
response to UV-B
response to gamma radiation
regulation of DNA-templated transcription, elongation
positive regulation of DNA-templated transcription, elongation
multicellular organism growth
photoreceptor cell maintenance
positive regulation of protein tyrosine kinase activity
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