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Invitrogen
PKM2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-120659
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 380-480 of human PKM2-specific (NP_0026453)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.9 mg/mL
Amount
90 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: HeLa, 293T, A-549, NIH/3T3, C6, Mouse skeletal muscle, Mouse heart, Rat skeletal muscle, Rat heart. The target is usually found in the following locations: Cytoplasm, Nucleus.
Immunogen sequence: LIAREAEAAI YHLQLFEELR RLAPITSDPT EATAVGAVEA SFKCCSGAII VLTKSGRSAH QVARYRPRAP IIAVTRNPQT ARQAHLYRGI FPVLCKDPVQ E
Target Information
PKM2 is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. PKM2 has been shown to interact with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. PKM2 has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms of PKM2 have been reported.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytosolic thyroid hormone-binding protein; cytosolic thyroid hormone-binding protein (EC 2.7.1.40); epididymis secretory protein Li 30; isozymes M1/M2; M2 pyruvate kinase; m2pk; OPA-interacting protein 3; PK, muscle type; pyruvate kinase 2/3; pyruvate kinase 3; pyruvate kinase isozymes M1/M2; pyruvate kinase muscle isozyme; pyruvate kinase, muscle; similar to human pyruvate kinase M2; threonine-protein kinase PKM2; thyroid hormone-binding protein 1; thyroid hormone-binding protein, cytosolic; tu; tumor M2-PK; tyrosine-protein kinase PKM2; unnamed protein product
Gene Aliases: CTHBP; HEL-S-30; OIP3; p58; PK; Pk-2; Pk-3; PK3; PKM12; PKM2; TCB; THBP1
UniProt ID: (Human) P14618, (Mouse) P52480, (Rat) P11980
Entrez Gene ID: (Human) 5315, (Mouse) 18746, (Rat) 25630
magnesium ion binding
transcription coactivator activity
RNA binding
mRNA binding
protein serine/threonine kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
pyruvate kinase activity
protein binding
MHC class II protein complex binding
potassium ion binding
histone kinase activity (H3-T11 specific)
protein homodimerization activity
cadherin binding
identical protein binding
ADP binding
protein dimerization activity
thyroid hormone binding
glycolytic process
chromatin remodeling
programmed cell death
cellular response to insulin stimulus
pyruvate biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
canonical glycolysis
positive regulation of sprouting angiogenesis
positive regulation of cytoplasmic translation
glucose metabolic process
response to hypoxia
liver development
response to nutrient
response to gravity
response to muscle inactivity
organ regeneration
response to insulin
skeletal muscle tissue regeneration
protein tetramerization
protein homotetramerization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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