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Invitrogen
LONP1 Polyclonal Antibody
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LONP1 Antibody (PA5-120887) in IHC (P)
Immunohistochemistry analysis of LONP1 in paraffin-embedded mouse kidney. Samples were incubated with LONP1 Polyclonal antibody (Product # PA5-120887) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-120887
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein (or fragment)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
2.7 mg/mL
规格
270 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: A-549, HL-60, LO2, HT-1080, BT-474, Mouse heart, Mouse kidney, Mouse liver, Rat kidney. The target is usually found in the following locations: Mitochondrion matrix.
Immunogen sequence: VFPHLPLIAI TRNPVFPRFI KIIEVKNKKL VELLRRKVRL AQPYVGVFLK RDDSNESDVV ESLDEIYHTG TFAQIHEMQD LGDKLRMIVM GHRRVHISRQ LEVEPEEPEA ENKHKPRRKS KRGKKEAEDE LSARHPAELA MEPTPELPAE VLMVEVENVV HEDFQVTEEV KALTAEIVKT IRDIIALNPL YRESVLQMMQ AGQRVVDNPI YLSDMGAALT GAESHELQDV LEETNIPKRL YKALSLLKKE FELSKLQQRL GREVEEKIKQ THRKYLLQEQ L
靶标信息
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia. Alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: h LonHS; hLON ATP-dependent protease; Lon protease homolog, mitochondrial; Lon protease-like protein; LONHs; LONP; Mitochondrial ATP-dependent protease Lon; mitochondrial chaperone LONP1; mitochondrial lon protease-like protein; protease, serine, 15; Serine protease 15; unnamed protein product
基因别名: 1200017E13Rik; CODASS; hLON; LON; LonHS; LONP; LONP1; PIM1; PRSS15
Entrez Gene ID: (Human) 9361, (Mouse) 74142, (Rat) 170916
mitochondrial RNA polymerase regulatory region DNA binding
single-stranded DNA binding
single-stranded RNA binding
ATP-dependent peptidase activity
serine-type endopeptidase activity
protein binding
ATP binding
ATPase activity
PH domain binding
identical protein binding
ADP binding
insulin receptor substrate binding
sequence-specific DNA binding
G-quadruplex DNA binding
DNA polymerase binding
ATP-dependent protein folding chaperone
response to hypoxia
'de novo' protein folding
proteolysis
misfolded or incompletely synthesized protein catabolic process
mitochondrion organization
response to hormone
response to aluminum ion
protein catabolic process
cellular response to oxidative stress
mitochondrial protein catabolic process
negative regulation of insulin receptor signaling pathway
regulation of peptidyl-tyrosine phosphorylation
chaperone-mediated protein complex assembly
protein-containing complex assembly
oxidation-dependent protein catabolic process
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