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APC6 Polyclonal Antibody
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FIGURE: 1 / 3
APC6 Antibody (PA5-121073) in IHC (P)
Immunohistochemistry analysis of APC6 in paraffin-embedded human gastric cancer. Samples were incubated with APC6 Polyclonal antibody (Product # PA5-121073) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-121073
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 371-620 of human CDC16 (NP_003894.3).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.89 mg/mL
Amount
189 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: Jurkat, HepG2, HeLa, A-549, Mouse brain, Mouse ovary, Rat brain. The target is usually found in the following locations: Cytoplasm, centrosome, cytoskeleton, microtubule organizing center, spindle.
Immunogen sequence: MLYIGLEYGL TNNSKLAERF FSQALSIAPE DPFVMHEVGV VAFQNGEWKT AEKWFLDALE KIKAIGNEVT VDKWEPLLNN LGHVCRKLKK YAEALDYHRQ ALVLIPQNAS TYSAIGYIHS LMGNFENAVD YFHTALGLRR DDTFSVTMLG HCIEMYIGDS EAYIGADIKD KLKCYDFDVH TMKTLKNIIS PPWDFREFEV EKQTAEETGL TPLETSRKTP DSRPSLEETF EIEMNESDMM LETSMSDHST
Target Information
The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: anaphase-promoting complex subunit 6; anaphase-promoting complex, subunit 6; CDC16; cell division cycle 16 homolog; cyclosome subunit 6; RP11-569D9.4; unnamed protein product
Gene Aliases: 2700071J12Rik; 2810431D22Rik; ANAPC6; APC6; CDC16Hs; CUT9
UniProt ID: (Human) Q13042, (Mouse) Q8R349
Entrez Gene ID: (Human) 8881, (Mouse) 69957, (Rat) 290875
regulation of mitotic cell cycle
protein ubiquitination
anaphase-promoting complex-dependent catabolic process
positive regulation of mitotic metaphase/anaphase transition
cell division
regulation of meiotic cell cycle
protein K48-linked ubiquitination
protein K11-linked ubiquitination
protein branched polyubiquitination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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