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Invitrogen
MPEG1 Polyclonal Antibody
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MPEG1 Antibody (PA5-121769) in IHC (P)
Immunohistochemistry of MPEG1 in paraffin-embedded human Breast cancer tissue. Samples were incubated in polyclonal MPEG1 antibody (Product # PA5-121768) using a dilution of 10 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG at a dilution of 2 µg/mL and DAB.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-121769
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Phe313-Ser580 (Accession Q2M385), with N-terminal His Tag
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
10 µg
纯化类型
Antigen affinity chromatography, Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The MPEG1 (Macrophage Expressed Gene 1) gene encodes a protein known as Perforin-2, which is part of the immune system and plays a crucial role in host defense mechanisms. Located on chromosome 11, MPEG1/Perforin-2 is primarily expressed in macrophages, dendritic cells, and other immune cells. The protein functions by forming pores in the membranes of pathogenic bacteria, leading to their lysis and destruction. This pore-forming capability is integral to the innate immune response, providing a rapid means to target and eliminate intracellular pathogens. MPEG1's activity contributes significantly to the antimicrobial arsenal of the innate immune system, and deficiencies in this protein can lead to increased susceptibility to infections. Ongoing research is focused on understanding how MPEG1/Perforin-2 can be leveraged or augmented to enhance immune responses and potential therapeutic applications in infectious disease and immunotherapy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Macrophage gene 1 protein; Macrophage-expressed gene 1 protein; MGC150002; MGC150003; P-2; Perforin-2
基因别名: MPEG1
Entrez Gene ID: (Human) 219972
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
