Invitrogen

GPR37 Polyclonal Antibody

Name: GPR37 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-13413
Availability: InStock

1 篇参考文献

查看其他10个GPR37抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (3)

GPR37 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 3

GPR37 Antibody (PA5-13413) in IHC (P)

Immunohistochemistry analysis of GPR37 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with GPR37 polyclonal antibody (Product # PA5-13413) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepa... View More

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

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Immunogen image

Immunogen Image GPR37 Polyclonal Antibody

产品信息

PA5-13413

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:100

产品规格

种属反应

Human, Mouse

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide between 217-246 amino acids from the C-terminal region of human Pael-R (GPR37)

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2 mg/mL

800 µg

纯化类型

Ammonium sulfate precipitation

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2112516

靶标信息

Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known; however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function. Panneuronal expression of Parkin substrate Pael-R causes age-dependent selective degeneration of Drosophila dopaminergic (DA) neurons; coexpression of Parkin degrades Pael-R and suppresses its toxicity.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: Endothelin B receptor-like protein 1; ETBR-LP-1; G-protein coupled receptor 37; Gpcr/cns1; Het-b-r-lp; Pael receptor; PAELR; parkin-associated endothelin B-like receptor; Parkin-associated endothelin receptor-like receptor; probable G-protein coupled receptor 37; Prosaposin receptor GPR37

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基因别名: AI848630; GPR37; Pael-R

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UniProt ID: (Mouse) Q9QY42

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Entrez Gene ID: (Mouse) 14763

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功能

signal transducer activity G-protein coupled receptor activity G-protein coupled peptide receptor activity Hsp70 protein binding heat shock protein binding ubiquitin protein ligase binding peptide binding G-protein coupled receptor transmembrane signal receptor

参与通路

signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway locomotion involved in locomotory behavior dopamine biosynthetic process positive regulation of MAPK cascade positive regulation of dopamine metabolic process negative regulation of hydrogen peroxide-induced cell death