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Invitrogen
ACVR1 Polyclonal Antibody
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ACVR1 Antibody (PA5-13881) in IHC (P)
Immunohistochemistry analysis of ACVR1 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with ACVR1 polyclonal antibody (Product # PA5-13881) which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-13881
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human Activin Receptor Type IA (ACVR1)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
2 mg/mL
规格
800 µg
纯化类型
Ammonium sulfate precipitation, Size-exclusion - Dialysis
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with bovine based on sequence homology.
靶标信息
Activin A receptor, type I (ACVR1) belongs to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. ACVR1 signals a specific transcriptional response in concert with activin type II receptors. The ACVR1 gene encodes activin A type I receptor, which signals a particular transcriptional response in concert with activin type II receptors. Mutations in ACVR1 have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: activin A receptor, type 1; Activin receptor type I; Activin receptor type-1; Activin receptor-like kinase 2; activin type I receptor; ACTR-I; ALK-2; ALK2-B; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I
基因别名: ACVR1; ACVRLK2
UniProt ID: (Rat) P80201
Entrez Gene ID: (Rat) 79558
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta receptor activity, type I
ATP binding
activin receptor activity, type I
growth factor binding
protein homodimerization activity
SMAD binding
metal ion binding
activin binding
transforming growth factor beta binding
serine/threonine protein kinase receptor
G1/S transition of mitotic cell cycle
patterning of blood vessels
urogenital system development
in utero embryonic development
gastrulation with mouth forming second
mesoderm formation
neural crest cell migration
acute inflammatory response
embryonic heart tube morphogenesis
mitral valve morphogenesis
atrial septum primum morphogenesis
protein phosphorylation
transforming growth factor beta receptor signaling pathway
germ cell development
determination of left/right symmetry
gastrulation
mesoderm development
heart development
negative regulation of signal transduction
positive regulation of pathway-restricted SMAD protein phosphorylation
peptidyl-threonine phosphorylation
signal transduction by protein phosphorylation
regulation of ossification
positive regulation of bone mineralization
BMP signaling pathway
activin receptor signaling pathway
negative regulation of activin receptor signaling pathway
positive regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of skeletal muscle tissue development
smooth muscle cell differentiation
pharyngeal system development
pathway-restricted SMAD protein phosphorylation
cardiac muscle cell fate commitment
endocardial cushion cell fate commitment
cellular response to glucocorticoid stimulus
positive regulation of determination of dorsal identity
negative regulation of extrinsic apoptotic signaling pathway
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