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Invitrogen
Laminin Polyclonal Antibody
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FIGURE: 1 / 2
Laminin Antibody (PA5-143904) in IHC (P)
Immunohistochemistry (Paraffin) analysis of Laminin in paraffin-embedded section of human placenta tissue using Laminin Polyclonal Antibody (Product # PA5-143904). Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. The tissue section was then incubated with the primary antibody at a 2 µg/mL dilution overnight... View More
Product Details
PA5-143904
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Human fibroblasts derived.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Positive Control - WB: human placenta tissue, human HCCT tissue. IHC: human placenta tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
Laminin is a crucial glycoprotein that plays a significant role in the extracellular matrix, particularly within the basement membrane. It is composed of three subunits: alpha, beta, and gamma chains. These chains are disulfide-linked polypeptides that together form a heterotrimer, resembling the shape of a cross. The human genome encodes 11 genetically distinct laminin chains, which combine to form over 14 different laminin isoforms, each with specific tissue distributions and functions. Laminins can bind to other laminin molecules, as well as integrins and other matrix proteins, providing structural support and influencing cell differentiation, migration, and adhesion. These glycoproteins are vital during early embryonic development, where they contribute to the formation of basement membrane-like structures, even in the absence of type IV collagen. The evolutionary origin of laminin gene families can be traced back to early branching animals, providing insights into metazoan gene family development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Laminin A chain; laminin B1; Laminin B1 chain; Laminin B2 chain; laminin B2 precursor; Laminin M chain; Laminin subunit alpha-1; Laminin subunit alpha-2; Laminin subunit beta-1; Laminin subunit gamma-1; laminin, alpha 1; laminin, alpha 2; laminin, beta 1; laminin, gamma 1 (formerly LAMB2); Laminin-1 subunit alpha; Laminin-1 subunit beta; Laminin-1 subunit gamma; Laminin-10 subunit beta; Laminin-10 subunit gamma; Laminin-11 subunit gamma; Laminin-12 subunit alpha; Laminin-12 subunit beta; Laminin-2 subunit alpha; Laminin-2 subunit beta; Laminin-2 subunit gamma; Laminin-3 subunit alpha; Laminin-3 subunit gamma; Laminin-4 subunit alpha; Laminin-4 subunit gamma; Laminin-6 subunit beta; Laminin-6 subunit gamma; Laminin-7 subunit gamma; Laminin-8 subunit beta; Laminin-8 subunit gamma; Laminin-9 subunit gamma; Merosin heavy chain; mutant laminin subunit alpha 2; S-LAM alpha; S-LAM gamma; S-laminin subunit alpha; S-laminin subunit gamma; unnamed protein product
Gene Aliases: CLM; LAMA; LAMA1; LAMA2; LAMB1; LAMB2; LAMC1; LAMM; LIS5; MDC1A; PTBHS; S-LAM-alpha
UniProt ID: (Human) P25391, (Human) P24043, (Human) P07942, (Human) P11047
Entrez Gene ID: (Human) 284217, (Human) 3908, (Human) 3912, (Human) 3915
morphogenesis of an epithelial sheet
cell adhesion
cell surface receptor signaling pathway
tissue development
regulation of cell adhesion
regulation of cell migration
neuron projection development
establishment of epithelial cell apical/basal polarity
positive regulation of cell adhesion
regulation of embryonic development
positive regulation of muscle cell differentiation
retina development in camera-type eye
epithelial tube branching involved in lung morphogenesis
branching involved in salivary gland morphogenesis
retinal blood vessel morphogenesis
regulation of basement membrane organization
positive regulation of integrin-mediated signaling pathway
negative regulation of cell adhesion
embryo implantation
anatomical structure morphogenesis
cell migration
neuronal-glial interaction involved in cerebral cortex radial glia guided migration
positive regulation of cell migration
substrate adhesion-dependent cell spreading
endodermal cell differentiation
odontogenesis
positive regulation of epithelial cell proliferation
axon guidance
muscle organ development
Schwann cell differentiation
positive regulation of synaptic transmission, cholinergic
maintenance of blood-brain barrier
endoderm development
extracellular matrix disassembly
hemidesmosome assembly
protein-containing complex assembly
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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