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Invitrogen
PTGER2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5149999
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Prostaglandin E Receptor 2 (EP2) (Ala155-Gln355)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Prostaglandins are produced by the metabolism of arachidonic acid. Prostaglandin E2 is one of the five physiologically significant prostanoids known. Its wide spectrum of physiologic and pharmacologic effects in various tissues is mediated through binding to the Prostaglandin E2 receptors (EP1, EP2, EP3 & EP4). These include effects on the immune, endocrine, cardiovascular, renal and reproductive systems as well as smooth muscle. It is also one of the most abundant of the prostanoid family in the brain where it plays an important role in many neural functions, particularly in newborn babies, and as a mediator of inflammation. PGE-2 signals through a family of G-protein coupled receptors known as EP receptors. There are 4 subtypes of EP receptors, known as EP1, EP2, EP3 and EP4. EP2 receptors are 358 amino acid proteins with a short third intracellular loop. EP2 receptors stimulate adenylyl cyclase by their coupling to Gs and do not undergo PGE-2-induced internalization. The EP2 receptors is involved with the contration and relaxation of smooth muscle tissue. These receptors are mainly localized in lung and placental tissues and in smooth muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EP2 receptor; G-protein coupled receptor; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype; Pge2-r ep2; prostaglandin E receptor 2 (EP2 subtype); prostaglandin E receptor 2 (subtype EP2), 53kD; prostaglandin E receptor 2 (subtype EP2), 53kDa; prostaglandin E receptor EP2 subtype; prostaglandin E receptor subtype EP2; prostanoid EP2 receptor; unnamed protein product
Gene Aliases: COX-2; EP2; Ptgerep2
UniProt ID: (Human) P43116, (Mouse) Q62053
Entrez Gene ID: (Human) 5732, (Mouse) 19217
cAMP biosynthetic process
inflammatory response
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
negative regulation of cell proliferation
response to nematode
regulation of circadian sleep/wake cycle, wakefulness
positive regulation of bone mineralization
response to lipopolysaccharide
response to progesterone
negative regulation of interleukin-1 alpha production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
positive regulation of interleukin-10 production
positive regulation of interleukin-6 production
response to lipid
positive regulation of glial cell apoptotic process
positive regulation of ion transmembrane transport
regulation of cell proliferation
vasodilation
regulation of circadian sleep/wake cycle, REM sleep
positive regulation of neuron apoptotic process
positive regulation of osteoblast differentiation
positive regulation of ossification
negative regulation of smooth muscle contraction
positive regulation of circadian sleep/wake cycle, non-REM sleep
cAMP metabolic process
micturition
maternal process involved in female pregnancy
negative regulation of mucus secretion
cellular response to prostaglandin E stimulus
regulation of nitric oxide metabolic process
positive regulation of hippocampal neuron apoptotic process
negative regulation of hippocampal neuron apoptotic process
surfactant secretion
positive regulation of p38MAPK cascade
negative regulation of compound eye retinal cell apoptotic process
positive regulation of glutamate secretion, neurotransmission
negative regulation of microglial cell migration
positive regulation of gastric mucosal blood circulation
negative regulation of endothelin secretion
positive regulation of DNA biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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